Genes that control ray sensory neuron axon development in the Caenorhabditis elegans male.

Genetics
Lingyun Jia, S W Emmons

Abstract

We have studied how a set of male-specific sensory neurons in Caenorhabditis elegans establish axonal connections during postembryonic development. In the adult male, 9 bilateral pairs of ray sensory neurons innervate an acellular fan that serves as a presumptive tactile and olfactory organ during copulation. We visualized ray axon commissures with a ray neuron-specific reporter gene and studied both known and new mutations that affect the establishment of connections to the pre-anal ganglion. We found that the UNC-6/netrin-UNC-40/DCC pathway provides the primary dorsoventral guidance cue to ray axon growth cones. Some axon growth cones also respond to an anteroposterior cue, following a segmented pathway, and most or all also have a tendency to fasciculate. Two newly identified genes, rax-1 and rax-4, are highly specific to the ray neurons and appear to be required for ray axon growth cones to respond to the dorsoventral cue. Among other genes we identified, rax-2 and rax-3 affect anteroposterior signaling or fate specification and rax-5 and rax-6 affect ray identities. We identified a mutation in sax-2 and show that the sax-2/Furry and sax-1/Tricornered pathway affects ectopic neurite outgrowth and establishment of normal axo...Continue Reading

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Citations

Aug 10, 2006·Cell and Tissue Research·Mark SeifertRalf Baumeister
Jul 28, 2012·Science·Travis A JarrellScott W Emmons
Feb 23, 2011·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Song SongXun Huang
Sep 30, 2014·Wiley Interdisciplinary Reviews. Developmental Biology·Scott W Emmons
Jan 12, 2007·Proceedings of the National Academy of Sciences of the United States of America·Yong YangHong Zhang
Jun 27, 2014·PLoS Genetics·Tsai-Fang HuangYi-Chun Wu
Nov 15, 2011·Journal of Psychiatric and Mental Health Nursing·A Ghanizadeh
Dec 14, 2019·PLoS Genetics·Nicole F LiachkoBrian C Kraemer
Mar 22, 2018·Genetics·María I Lázaro-PeñaScott W Emmons

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