PMID: 16628009Apr 22, 2006Paper

Genesis and wanderings: origins and migrations in asymmetrically replicating mitochondrial DNA

Cell Cycle
Timothy A Brown, D A Clayton

Abstract

Mammalian mitochondria maintain a small circular genome that encodes RNA and polypeptides that are essential for the generation of ATP through oxidative phosphorylation. The mechanism of replication of mammalian mitochondrial DNA (mtDNA) has recently been a topic of controversy. New evidence has led to a modified strand-displacement model that reconciles much of the current data. This revision stems from a new appreciation for alternative light-strand origins. We consider here some of the potential mechanisms for light-strand origin initiation. We also consider further the susceptibility of branch migration within replicating mtDNA molecules. The existence of alternative light-strand origins and a propensity for branch migration in replicating mtDNA molecules exposes a new array of possible configurations of mtDNA. The assortment and assignment of these forms is relevant to the interpretation of experimental data and may also yield insight into the molecular basis of replication errors.

Citations

Mar 1, 2012·Journal of Molecular Evolution·Juliette ArabiAlexandre Hassanin
Nov 7, 2008·The Journal of Biological Chemistry·Timothy A BrownDavid A Clayton
Feb 27, 2007·PLoS Genetics·Gregory C KujothTomas A Prolla
May 5, 2009·Mitochondrion·Ester López-GallardoEduardo Ruiz-Pesini
Dec 13, 2006·Biochimie·Hongliang ZhangYves Pommier
Aug 15, 2006·Journal of Theoretical Biology·Hervé SeligmannBasuthkar J Rao
Apr 27, 2010·Biochimica Et Biophysica Acta·Sjoerd Wanrooij, Maria Falkenberg
Jul 13, 2012·Current Protocols in Human Genetics·Mitchell M Holland
Jun 30, 2018·PloS One·Jaakko L O PohjoismäkiHeidi Anderson

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