PMID: 19923909Nov 20, 2009Paper

Genetic ablation of caveolin-1 increases neural stem cell proliferation in the subventricular zone (SVZ) of the adult mouse brain

Cell Cycle
Jean-François JasminM P Lisanti

Abstract

Adult neural stem cells are self-renewing multipotent cells that have the potential to replace dysfunctional and/or dying neuronal cells at the site of brain injury or degeneration. Caveolins are well-known tumor-suppressor genes that were recently found to be involved in the regulation of stem cell proliferation. For instance, ablation of the caveolin-1 (Cav-1) gene in mice markedly increases the proliferation of intestinal and mammary stem cells. However, the roles of caveolins in the proliferation of adult neural stem cells still remain unknown. In this study, dual-label immunofluorescence analysis of the proliferation marker, Ki67, and the stem cell markers, nestin and Sox2, was performed on brains of 8 week-old wild-type (WT) and Cav-1 knockout (KO) mice. Our results demonstrate an increased number of Ki67-positive nuclei in the subventricular zone (SVZ) of Cav-1 KO brains. Importantly, our dual-label immunofluorescence analyses demonstrate increased co-localization of Ki67 with both nestin and Sox2 in the SVZ of Cav-1 KO brains. Remarkably similar results were also obtained with Cav-2 and Cav-3 KO mouse brains as well, with increased proliferation of adult neural stem cells. Thus, the SVZ of caveolin KO mouse brains displ...Continue Reading

Citations

Sep 14, 2010·Nature Genetics·Gudmar ThorleifssonKari Stefansson
Sep 21, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ranmal Aloka SamarasingheDonald B DeFranco
Jan 10, 2012·Biochemistry Research International·Grzegorz Sowa
May 20, 2014·Cell Biochemistry and Biophysics·Gabriele BonaventuraEnrico Gratton
Oct 4, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Shuyang WangYanjie Jia
Mar 19, 2011·Biochemical and Biophysical Research Communications·Yue LiJiangang Shen
Jul 19, 2012·Journal of Cellular Biochemistry·Natasha BakerRocky S Tuan
Jun 15, 2016·Scientific Reports·Shi Song RongChi Pui Pang
Mar 26, 2016·Stroke; a Journal of Cerebral Circulation·Kang-Ho ChoiKi-Hyun Cho
Nov 22, 2018·Phytotherapy Research : PTR·Ronghua YangJulin Xie
Nov 21, 2013·American Journal of Physiology. Endocrinology and Metabolism·Corine MartineauRobert Moreau
Sep 10, 2021·Journal of Cancer Research and Clinical Oncology·Xingning LaiLixia Xiong

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