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Genetic adaptation to high altitude in the Ethiopian highlands

Genome Biology

Jan 24, 2012

Laura B ScheinfeldtSarah A Tishkoff

Abstract

Genomic analysis of high-altitude populations residing in the Andes and Tibet has revealed several candidate loci for involvement in high-altitude adaptation, a subset of which have also been shown to be associated with hemoglobin levels, including EPAS1, EGLN1, and PPARA, which play a ...read more

Mentioned in this Paper

Mitochondrial Membrane Transport Proteins
Genome-Wide Association Study
Biochemical Pathway
EGLN1
Genome
MICU1
ARNT2 wt Allele
Candidate Disease Gene
PPARA gene
MICU1 gene
10
1
1
166
1
Paper Details
References
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  • Citations86
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Molecular Genetics and Metabolism

Metabolic insight into mechanisms of high-altitude adaptation in Tibetans

Molecular Genetics and MetabolismApril 17, 2012
RiLi GeDonald A McClain
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Genetic adaptation to high altitude in the Ethiopian highlands

Genome Biology

Jan 24, 2012

Laura B ScheinfeldtSarah A Tishkoff

PMID: 22264333

DOI: 10.1186/gb-2012-13-1-r1

Abstract

Genomic analysis of high-altitude populations residing in the Andes and Tibet has revealed several candidate loci for involvement in high-altitude adaptation, a subset of which have also been shown to be associated with hemoglobin levels, including EPAS1, EGLN1, and PPARA, which play a ...read more

Mentioned in this Paper

Mitochondrial Membrane Transport Proteins
Genome-Wide Association Study
Biochemical Pathway
EGLN1
Genome
MICU1
ARNT2 wt Allele
Candidate Disease Gene
PPARA gene
MICU1 gene
10
1
1
166
1

Similar Papers Found In These Feeds

Open Access Genomics Journals

Discover the latest genomics research in this collection of the top open access genomics journals.

Renal Hypoxia & Ischemia

Acute renal failure is most commonly caused by ischemia. Ischemic-induced renal tissue hypoxia is thought to be a major component in the development of acute renal failure in promoting the initial tubular damage. Here is the latest research.

Related Papers

Molecular Genetics and Metabolism

Metabolic insight into mechanisms of high-altitude adaptation in Tibetans

Molecular Genetics and MetabolismApril 17, 2012
RiLi GeDonald A McClain
Paper Details
References
  • References38
  • Citations86
1234
  • References38
  • Citations86
12345...
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