Genetic admixture estimates by Alu elements in Afro-Colombian and Mestizo populations from Antioquia, Colombia

Annals of Human Biology
Luis Gómez-PérezJ A Peña

Abstract

This work was intended to gain insights into the admixture processes occurring in Latin American populations by examining the genetic profiles of two ethnic groups from Antioquia (Colombia). To analyse the genetic variability, eight Alu insertions were typed in 64 Afro-Colombians and a reference group of 34 Hispanics (Mestizos). Admixture proportions were estimated using the Weighted Least Squares and the Gene Identity methods. The usefulness of the Alu elements as Ancestry Informative Markers (AIMs) was evaluated through differences in weighted allelic frequencies (delta values) and by hierarchical analysis of the molecular variance (AMOVA). The Afro-Colombian gene pool was largely determined by the African component (88.5-88.8%), but the most prominent feature was the null contribution of European genes. Mestizos were characterized by a major European component (60.0-63.8%) and a comparatively low proportion of Amerindian (19.2-20.7%) and African (17.0-19.3%) genes. Five of the Alu loci examined (ACE, APO, FXIIIB, PV92 and TPA25) showed an adequate resolving power to differentiate between continental groups, as indicated by delta values and AMOVA results. The peculiarity of the Afro-Colombian gene pool seems to be associated ...Continue Reading

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Citations

Feb 15, 2011·American Journal of Human Biology : the Official Journal of the Human Biology Council·Luis Gómez-PérezJosé A Peña
Jul 16, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Juan Camilo Chacón-DuqueGabriel Bedoya
Apr 26, 2014·Genetics and Molecular Biology·Francisco Mauro Salzano, Mónica Sans

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