Genetic affinities of north and northeastern populations of India: inference from HLA-based study

Tissue Antigens
Suraksha AgrawalTapas K Chaudhuri

Abstract

India is like a microcosm of the world in terms of its diversity; religion, climate and ethnicity which leads to genetic variations in the populations. As a highly polymorphic marker, the human leukocyte antigen (HLA) system plays an important role in the genetic differentiation studies. To assess the genetic diversity of HLA class II loci, we studied a total of 1336 individuals from north India using DNA-based techniques. The study included four endogamous castes (Kayastha, Mathurs, Rastogies and Vaishyas), two inbreeding Muslim populations (Shias and Sunnis) from north India and three northeast Indian populations (Lachung, Mech and Rajbanshi). A total of 36 alleles were observed at DRB1 locus in both Hindu castes and Muslims from north, while 21 alleles were seen in northeast Indians. At the DQA1 locus, the number of alleles ranged from 11 to 17 in the studied populations. The total number of alleles at DQB1 was 19, 12 and 20 in the studied castes, Muslims and northeastern populations, respectively. The most frequent haplotypes observed in all the studied populations were DRB1*0701-DQA1*0201-DQB1*0201 and DRB1*1501-DQA1*0103-DQB1*0601. Upon comparing our results with other world populations, we observed the presence of Caucas...Continue Reading

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Citations

Sep 9, 2011·Journal of Human Genetics·Monojit DebnathYa-Ping Zhang
Aug 26, 2009·Journal of Gastroenterology and Hepatology·Adrian G Cummins, Ian C Roberts-Thomson
Jul 12, 2011·Human Biology·Maria Eugenia RiccioAlicia Sanchez-Mazas
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Dec 1, 2016·Journal, Genetic Engineering & Biotechnology·Avishek DasTapas Kumar Chaudhuri
Oct 8, 2019·HLA : Immune Response Genetics·Chenole KeppenUma Kanga

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