Genetic African Ancestry and Markers of Mineral Metabolism in CKD

Clinical Journal of the American Society of Nephrology : CJASN
Orlando M GutiérrezMyles Wolf

Abstract

Disorders of mineral metabolism are more common in African Americans with CKD than in European Americans with CKD. Previous studies have focused on the differences in mineral metabolism by self-reported race, making it difficult to delineate the importance of environmental compared with biologic factors. In a cross-sectional analysis of 3013 participants of the Chronic Renal Insufficiency Cohort study with complete data, we compared markers of mineral metabolism (phosphorus, calcium, alkaline phosphatase, parathyroid hormone, fibroblast growth factor 23, and urine calcium and phosphorus excretion) in European Americans versus African Americans and separately, across quartiles of genetic African ancestry in African Americans (n=1490). Compared with European Americans, African Americans had higher blood concentrations of phosphorus, alkaline phosphatase, fibroblast growth factor 23, and parathyroid hormone, lower 24-hour urinary excretion of calcium and phosphorus, and lower urinary fractional excretion of calcium and phosphorus at baseline (P<0.001 for all). Among African Americans, a higher percentage of African ancestry was associated with lower 24-hour urinary excretion of phosphorus (Ptrend<0.01) in unadjusted analyses. In l...Continue Reading

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References

Aug 1, 1985·The Journal of Clinical Investigation·N H BellJ Shary
Sep 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·N H BellJ R Shary
Jan 12, 1999·British Journal of Urology·N A WhalleyA M Meyers
Mar 12, 2003·The Journal of Clinical Endocrinology and Metabolism·R J BryantC M Weaver
Jun 24, 2003·Journal of the American Society of Nephrology : JASN·Harold I FeldmanUNKNOWN Chronic Renal Insufficiency Cohort (CRIC) Study Investigators
Nov 4, 2006·Journal of the American Society of Nephrology : JASN·Carmen A PeraltaMichael Shlipak
Jan 12, 2007·Journal of the American Society of Nephrology : JASN·Eric N Taylor, Gary C Curhan
Jun 23, 2009·Clinical Journal of the American Society of Nephrology : CJASN·James P LashUNKNOWN Chronic Renal Insufficiency Cohort (CRIC) Study Group
Jun 10, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Orlando M GutiérrezMyles Wolf
Sep 18, 2010·Journal of the American Society of Nephrology : JASN·Orlando M GutiérrezUNKNOWN CRIC Study Group
Oct 15, 2010·The New England Journal of Medicine·Charles N Rotimi, Lynn B Jorde
May 26, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Hartmut H MallucheMarie-Claude Monier-Faugere
Jun 5, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Amanda Hyre AndersonUNKNOWN CRIC Study Investigators
Jan 3, 2013·Annals of Human Genetics·Nuri KodamanScott M Williams
Nov 12, 2013·The New England Journal of Medicine·Afshin ParsaUNKNOWN CRIC Study Investigators

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Citations

Sep 16, 2016·The American Journal of Clinical Nutrition·Ranee Chatterjee, Pao-Hwa Lin
Sep 2, 2020·The Journal of Clinical Endocrinology and Metabolism·Simon HsuCassianne Robinson-Cohen
Aug 9, 2017·American Journal of Nephrology·Kimberly HardingSusanne B Nicholas
Jul 19, 2017·Annual Review of Nutrition·Lindsay R Pool, Myles Wolf
Sep 30, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Marciana LasterKamyar Kalantar-Zadeh
Aug 9, 2017·American Journal of Nephrology·Kimberly HardingSusanne B Nicholas
Mar 11, 2021·Postgraduate Medical Journal·Ziying LinBernard M Y Cheung
Mar 27, 2019·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Landon BrownUNKNOWN CRIC Study Investigators

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