PMID: 29478993Feb 27, 2018Paper

Genetic algorithm for making pharmacotherapy decision in the patients with multimorbidity: approaches for clinicians

Wiadomości lekarskie : organ Polskiego Towarzystwa Lekarskiego
Viktor M BobyryovOlena V Vlasova

Abstract

Purpose of our investigation was to propose and verify the algorithm for making pharmacotherapy decision in the patients with multimorbidity. Material and methods: Object of investigation: patients with multimorbidity. Observations were conducted according to European Guidelines. We proposed and tested genetic algorithm for making pharmacotherapy decision for such patients. It is necessary to mention, that each person is representing a variant of treating with certain pathology. Chromosome of this variant is composed from genes, where each gene is certain group of drugs. The sequence of solutions of this problem comes down to the selection of drugs for the di-morbid conditions as the descendants of mono-morbidity. At the next stage of selection continues the most successful combinations of drugs for multimorbid conditions as descendants di-morbid and monomorbid conditions. When breeding pairs must take into account the mutual potentiating pathogenic and / or sanogenetic effects. Results: We had optimal patient's treatment as a result of crossing genes, groups of drugs and obtaining their offspring with the best combination without absolute contraindications and minimal relative contraindications. Conclusion: Thus, genetic algor...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

BMJ : British Medical Journal
Bruce GuthrieStewart W Mercer
The British Journal of General Practice : the Journal of the Royal College of General Practitioners
Frances S Mair, Katie I Gallacher
The British Journal of General Practice : the Journal of the Royal College of General Practitioners
Jon Bickford, Alan Cohen
The Journal of the American Academy of Psychiatry and the Law
Alan R Felthous, Matthew S Stanford
© 2022 Meta ULC. All rights reserved