Genetic alteration of normal aging processes is responsible for extended longevity in Drosophila

Developmental Genetics
R Arking, R Wells

Abstract

The first step in a genetic analysis of aging is to identify and characterize the genetic mutants and their controls that will be used. Such mutants or strains are initially identified by their effect on the life span. Yet many genetic interventions are known to have some effect on the life span without necessarily affecting the aging process. It is therefore necessary to prove that one is actually dealing with an aging mutant before one draws strong inferences from the data. Casarett's rules provide an operational test for doing so, relying as they do on the comparison of aging bio-markers in the experimental and reference strains. We show that our previously described genetically based long-lived NDC-L strain and its normal-lived NDC-R control strain differ only in the chronological age of expression of two behavioral and three physiological functional age biomarkers. They do not differ in the sequence or the physiological age of expression of these biomarkers. These two strains comply with the Casarett rules and thereby comprise a valid tool with which to conduct a comparative genetic analysis of aging. The implications of the available data are discussed, including the possibility that aging in these strains of Drosophila m...Continue Reading

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Citations

Oct 1, 2001·Journal of the American Aging Association·S A Buck, R Arking
Sep 1, 2005·Age·Luc Poirier, Laurent Seroude
Jan 1, 1996·Experimental Gerontology·G M Martin
Apr 11, 2001·Experimental Gerontology·D J HolmesS N Austad
Feb 1, 2003·Experimental Gerontology·Eric Cook-Wiens, Michael S Grotewiel
Jan 12, 2012·Rejuvenation Research·Parvin ShahrestaniMichael R Rose
Oct 31, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Robert ArkingMark Lane
May 31, 1994·Annals of the New York Academy of Sciences·Z Zakeri, R A Lockshin
Aug 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jie ZhengLaurent Seroude
May 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Cheng HuangKerry Kornfeld
Jan 29, 2008·Aging Cell·Sean RamsdenLaurent Seroude
Jun 1, 2005·Aging Cell·Ian MartinMichael S Grotewiel
Jun 20, 2020·Genome Génome / Conseil National De Recherches Canada·Taylor BarwellLaurent Seroude
Mar 30, 2019·Aging·Alexandros GaitanidisChristos Consoulas
Jan 25, 2002·Annals of the New York Academy of Sciences·R Arking
Oct 1, 1993·Evolution; International Journal of Organic Evolution·Marc TatarJames W Vaupel
Apr 25, 2018·Journal of Neurogenetics·Atsushi UedaAtulya Iyengar
Dec 16, 2020·Evolution; International Journal of Organic Evolution·Eevi SavolaCraig Walling
Feb 16, 2021·Frontiers in Cell and Developmental Biology·Olena OdnokozSvetlana N Radyuk
Jul 19, 2005·Ageing Research Reviews·Michael S GrotewielEric Cook-Wiens
Mar 11, 2006·Mechanisms of Ageing and Development·Ian Martin, Michael S Grotewiel
Aug 31, 2010·Experimental Gerontology·Melanie A Jones, Mike Grotewiel

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