Genetic alterations crossing the borders of distinct hematopoetic lineages and solid tumors: Diagnostic challenges in the era of high-throughput sequencing in hemato-oncology

Critical Reviews in Oncology/hematology
Evgenii ShumilovUlrike Bacher

Abstract

Owing to the introduction of next-generation sequencing (NGS) new challenges for diagnostic algorithms and the interpretation of the results for therapeutic decision making in hemato-oncology have arisen. Recurrent somatic mutations crossing the borders between different hematological entities and solid neoplasms have been detected. In analogy to mutant TP53, the same mutation type may occur in myeloid, B- or T-lymphatic malignancies or solid neoplasms. At the same time, a certain mutation can show different prognostic outcomes in different entities and co-existence of certain mutations may change the prognostic relevance. These insights may spark the investigation of targeted therapies with the same substances across different disease entities. This review article summarizes mutations that can emerge in different hematologic and solid malignancies and summarizes other obstacles in the era of modern molecular diagnostics, such as the phenomenon of "clonal hematopoiesis of indeterminate potential" being difficult to interpret in the individual patient.

Citations

Mar 14, 2019·JAMA Cardiology·Oscar Calvillo-ArgüellesPaaladinesh Thavendiranathan
Sep 20, 2020·International Journal of Cancer. Journal International Du Cancer·Leonie W WahjudiStefan Wiemann
Jun 23, 2021·American Journal of Clinical Pathology·Mehenaz HanbazazhDiana Morlote

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Sequencing

Several sequencing approaches are employed to understand and examine tumor development and progression. These include whole genome as well as RNA sequencing. Here is the latest research on cancer sequencing.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Steffen Boettcher, Benjamin L Ebert
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
Y H Ding, Y F Li
© 2022 Meta ULC. All rights reserved