Genetic alterations in acinic cell carcinoma of the parotid gland determined by microsatellite analysis

Cancer Genetics and Cytogenetics
Adel K El-NaggarJohn G Batsakis

Abstract

We investigated, for the first time, the genetic alterations at certain chromosomal loci in 25 primary parotid acinic cell carcinomas to define the most frequently altered chromosomal regions and their association with pathologic features and DNA content analysis. Our results showed that 21 (84.0%) of the tumors had alteration in at least one of the loci tested. In general, chromosomal regions at chromosomes 4p, 5q, 6p, and 17p were more frequently altered than those on chromosomes 1p and 1q, 4q, 5p, and 6q. Certain markers at 4p15-16, 6p25-qter, and 17p11 regions showed the highest incidence of LOH, suggesting the presence of tumor suppressor genes associated with the oncogenesis of these tumors. LOH was significantly associated only with tumor grade. No apparent correlation between LOH and other clinicopathologic and DNA content characteristics was identified. Our study broadly defined the chromosomal arms and loci that may be targeted for further localization of the minimally deleted regions involved in the tumorigenesis of these tumors.

References

Jun 13, 1975·Radiation and Environmental Biophysics·H BaischW A Linden
Oct 1, 1992·Acta Pathologica Japonica·S FujitaH Okabe
Jan 1, 1991·Cancer·J E LewisL H Weiland
Feb 1, 1990·Cancer Genetics and Cytogenetics·J SandrosJ Mark
Nov 1, 1990·The Annals of Otology, Rhinology, and Laryngology·J G BatsakisA K el-Naggar
May 1, 1990·The Journal of Laryngology and Otology·A K el-NaggarR M Byers
Oct 1, 1989·The Journal of Laryngology and Otology·J G BatsakisA el-Naggar
Aug 1, 1989·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A P ChaudhryG M Yamane
Oct 19, 1994·Journal of the National Cancer Institute·X LiP D Nisen
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·L MaoD Sidransky
Jun 1, 1997·The American Journal of Surgical Pathology·A K el-NaggarJ G Batsakis
Nov 28, 1997·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·A GillenwaterA K El-Naggar
Dec 29, 1999·Genes, Chromosomes & Cancer·A K El-NaggarJ G Batsakis

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Citations

Mar 8, 2011·Journal of Medical Case Reports·Nabil N Al-Zaher, Amani A Obeid
Jan 8, 2008·World Journal of Gastroenterology : WJG·Hai-Tao ZhengZhi-Hai Peng
Dec 22, 2015·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·V Vander PoortenA Ferlito
Sep 19, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Natheer H Al-RawiSausan Al Kawas
Jul 20, 2005·Neoplasia : an International Journal for Oncology Research·Micaela PoetschBritta Kleist
Jan 13, 2010·Hematology/oncology and Stem Cell Therapy·Nabil Al-ZaherBassam Sulaiman Al-Kayyali
Dec 15, 2017·Journal of Pediatric Hematology/oncology·Shifra AshMeora Feinmesser
Sep 18, 2008·FEMS Yeast Research·Mette D JacobsenFrank C Odds
May 6, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·M CavaliereM Iemma
Jul 29, 2020·Journal of Cancer Research and Therapeutics·Sharlene Sara BabuAnuna Laila Mathew
Dec 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michelle D WilliamsAdel K El-Naggar
Oct 28, 1999·Archives of Pathology & Laboratory Medicine·P L DepowskiJ S Ross

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