Genetic alterations in combined neuroendocrine neoplasms of the lung

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Tiziana D'AddaCesare Bordi

Abstract

Large-cell neuroendocrine and small-cell lung carcinomas are highly aggressive neuroendocrine tumors that can be associated in a variant of 'small-cell lung carcinoma combined with large-cell neuroendocrine carcinoma'. Little is known about this rare tumor type with biphenotypic neuroendocrine differentiation. The aim of the present study was to genetically characterize each component of a series of combined small-cell/large-cell neuroendocrine carcinomas, to gain information on their histogenesis and to compare the alterations observed with those found in their respective pure forms. To this end, 22 formalin-fixed, paraffin-embedded lung neuroendocrine tumors obtained from surgical resections were investigated: six combined small-cell/large-cell carcinomas, eight pure large-cell carcinomas and eight pure small-cell carcinomas. For the combined neuroendocrine neoplasms, DNA was extracted separately from each of the two cytologically different populations. Allelic imbalance was investigated by PCR amplification of 30 highly polymorphic microsatellite markers located at 11 different chromosomal regions. A common background of genetic alterations, similar in both components of the combined neoplasms, was demonstrated at 17p13.1, 3...Continue Reading

References

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Jul 16, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Daniela FurlanCarlo Capella
Dec 4, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Tiziana D'AddaCesare Bordi
Dec 31, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hisao AsamuraKanji Nagai
Aug 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lorena BottarelliCesare Bordi

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Citations

Jan 22, 2010·BMC Bioinformatics·Russell Schwartz, Stanley E Shackney
Jan 31, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Timon P H BuysMing-Sound Tsao
Feb 21, 2009·American Journal of Clinical Pathology·Patrick L WagnerAnjali Saqi
Dec 30, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Elisabetta FroioGuido Rindi
Aug 22, 2014·Pathology International·Tetsuya EndoHiroshi Kamma
May 15, 2012·Biochimica Et Biophysica Acta·Dorian R A SwartsErnst-Jan M Speel
Jun 14, 2008·Virchows Archiv : an International Journal of Pathology·Giovanni FellegaraGuido Rindi
Oct 8, 2020·Histopathology·Ann E WaltsAlberto M Marchevsky
Jul 1, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity

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