Genetic Alterations in Gastric Cancer Associated with Helicobacter pylori Infection

Frontiers in Medicine
Claudia I Rivas-OrtizGonzalo Castillo-Rojas

Abstract

Gastric cancer is a world health problem and depicts the fourth leading mortality cause from malignancy in Mexico. Causation of gastric cancer is not only due to the combined effects of environmental factors and genetic variants. Recent molecular studies have transgressed a number of genes involved in gastric carcinogenesis. The aim of this review is to understand the recent basics of gene expression in the development of the process of gastric carcinogenesis. Genetic variants, polymorphisms, desoxyribonucleic acid methylation, and genes involved in mediating inflammation have been associated with the development of gastric carcinogenesis. Recently, these genes (interleukin 10, Il-17, mucin 1, β-catenin, CDX1, SMAD4, SERPINE1, hypoxia-inducible factor 1 subunit alpha, GSK3β, CDH17, matrix metalloproteinase 7, RUNX3, RASSF1A, TFF1, HAI-2, and COX-2) have been studied in association with oncogenic activation or inactivation of tumor suppressor genes. All these mechanisms have been investigated to elucidate the process of gastric carcinogenesis, as well as their potential use as biomarkers and/or molecular targets to treatment of disease.

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Citations

May 17, 2018·Genetics and Molecular Biology·Danilo do Rosário PinheiroBarbara do Nascimento Borges
Aug 5, 2018·Journal of Cellular Physiology·Sadegh FattahiHaleh Akhavan-Niaki
Aug 11, 2018·Environmental and Molecular Mutagenesis·Zareen SultanaMadhusudan Das
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Jun 7, 2019·Journal of Cellular Physiology·Bahman YousefiMajid Eslami
Aug 9, 2019·Indian Journal of Clinical Biochemistry : IJCB·Fariba NabatchianKamran Ghaedi
May 23, 2020·Clinical and Experimental Gastroenterology·Lina ElsalemOsama Aloudat
Jun 19, 2020·TheScientificWorldJournal·Abdalbasit Adam Mariod, Suzy Munir Salama
Sep 24, 2020·International Journal of Molecular Sciences·Nina Milutin GašperovMagdalena Grce
Sep 29, 2019·World Journal of Gastrointestinal Oncology·Athanasios KoulisAlex Boussioutas
Nov 17, 2020·Frontiers in Cellular and Infection Microbiology·Eduardo Mucito-VarelaYolanda López-Vidal
Sep 4, 2021·Journal of Gastrointestinal Cancer·Maryam GholamalizadehNaser Kalantari

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Methods Mentioned

BETA
nuclear translocation
ubiquitination
chemical modification
X-ray
biopsies

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