PMID: 7529548Oct 1, 1994Paper

Genetic alterations in localized prostate cancer: identification of a common region of deletion on chromosome arm 18q

Genes, Chromosomes & Cancer
Alain LatilR Lidereau

Abstract

Accumulation of mutations in oncogenes and tumor suppressor genes transforms a normal cell into a malignant cell by allowing it to escape from normal control of growth. In prostate tumorigenesis, the current model envisages specific mutations of the TP53 tumor suppressor gene and loss of loci, detected by loss of heterozygosity (LOH), on chromosome arms 8p, 10q, 16q, and 18q. In order to determine if alterations frequently found in other adenocarcinomas (breast, ovarian, gastric, colorectal), including losses of genetic material from chromosome arms 1p, 3p, 7q, 8p, 11p, 17p, 17q, and 18q, are also involved in prostate cancer, we examined 20 localized early-stage prostate tumors. We detected no mutations of the TP53 gene. Allelic losses were found from 7q (33%), 8p (50%), 10q (20%), and 18q (33%). Furthermore, as the first step toward isolating tumor suppressor genes on 18q, we used six polymorphic markers and identified a small common deleted region between the chromosome 18 centromere and the D18S19 locus.

References

Jan 1, 1992·Genes, Chromosomes & Cancer·R LundgrenF Mitelman
Sep 1, 1992·Cancer Genetics and Cytogenetics·A R BrothmanP F Schellhammer
Oct 29, 1992·Nature·J WeissenbachM Lathrop
Mar 15, 1992·Cancer·R CallahanR Lidereau
May 1, 1992·Human Genetics·R Lidereau, T Soussi
Jan 1, 1991·Acta Oncologica·V P CollinsP Ekman
Nov 1, 1991·Genomics·K KunimiV P Collins
May 1, 1991·Genes, Chromosomes & Cancer·U S BergerheimP Ekman
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D M HockenberyS J Korsmeyer
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·B S CarterW B Isaacs
Jan 1, 1985·Human Genetics·N B Atkin, M C Baker
Jan 1, 1993·Virchows Archiv. A, Pathological Anatomy and Histopathology·R P HenkeP Hammerer

❮ Previous
Next ❯

Citations

Aug 1, 1996·The Prostate·D G BostwickA Lopez-Beltran
Mar 4, 2000·International Journal of Cancer. Journal International Du Cancer·S S PadaleckiR J Leach
Feb 15, 2001·Genes, Chromosomes & Cancer·S S PadaleckiR J Leach
Jul 4, 2001·The Prostate·M SchmelzR B Nagle
Jul 11, 2006·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·J Chaudhary, M Schmidt
Dec 1, 1995·Cancer Genetics and Cytogenetics·B J WilliamsA R Brothman
Oct 9, 1996·Biochimica Et Biophysica Acta·E R Fearon
Jul 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K R Cho, E R Fearon
Aug 1, 1997·Cancer Genetics and Cytogenetics·I M FraylingI P Tomlinson
Aug 26, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M A KuczykU Jonas
Mar 16, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J TakitaJ Yokota
Dec 2, 2004·Nature Reviews. Cancer·Hirofumi Arakawa
Apr 28, 2007·Proceedings of the National Academy of Sciences of the United States of America·Deepak KamnasaranAbhijit Guha
Nov 30, 2006·DNA and Cell Biology·Mei SunShiv Srivastava
May 29, 2009·Carcinogenesis·Jovanny ZabaletaAugusto C Ochoa
Aug 6, 1999·Cancer Investigation·R S VermaC J Godec
Jan 1, 1996·Progress in Histochemistry and Cytochemistry·J C Alers, H van Dekken
Nov 18, 2003·International Journal of Cancer. Journal International Du Cancer·Maurizio ScaltritiSaverio Bettuzzi
Nov 11, 2005·Genes, Chromosomes & Cancer·Audrey GagnonMario Chevrette
Jul 1, 1996·Human Pathology·J J KönigA Hagemeijer
Apr 30, 2005·Cancer Genetics and Cytogenetics·Sei-Ichi MatsuiJohn K Cowell
Mar 24, 1998·Japanese Journal of Cancer Research : Gann·K UedaY Miyoshi
Aug 18, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patrick Mehlen, Eric R Fearon
Feb 1, 1996·The Journal of Urology·B J WilliamsA R Brothman
Feb 27, 1999·Endocrine Reviews·E RuijterJ Schalken
Jun 1, 2002·Journal of the American Society of Nephrology : JASN·Yasuo ImanishiAndrew Arnold
Aug 1, 2009·Archives of Pathology & Laboratory Medicine·A Craig MackinnonHikmat A Al-Ahmadie

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.