Genetic alterations within TLR genes in development of Toxoplasma gondii infection among Polish pregnant women

Advances in Medical Sciences
W WujcickaDorota Nowakowska

Abstract

The research was conducted to evaluate the role of genotypes, haplotypes and multiple-SNP variants in the range of TLR2, TLR4 and TLR9 single nucleotide polymorphisms (SNPs) in the development of Toxoplasma gondii infection among Polish pregnant women. The study was performed for 116 Polish pregnant women, including 51 patients infected with T. gondii, and 65 age-matched control pregnant individuals. Genotypes in TLR2 2258 G>A, TLR4 896 A>G, TLR4 1196 C>T and TLR9 2848 G>A SNPs were estimated by self-designed, nested PCR-RFLP assays. Randomly selected PCR products, representative for distinct genotypes in the studied polymorphisms, were confirmed by sequencing. All the genotypes were calculated for Hardy-Weinberg (H-W) equilibrium and TLR4 variants were tested for linkage disequilibrium. Relationships were assessed between alleles, genotypes, haplotypes or multiple-SNP variants in TLR polymorphisms and the occurrence of T. gondii infection in pregnant women, using a logistic regression model. All the analyzed genotypes preserved the H-W equilibrium among the studied groups of patients (P>0.050). Similar distribution of distinct alleles and individual genotypes in TLR SNPs, as well as of haplotypes in TLR4 polymorphisms, were ob...Continue Reading

Citations

Jun 9, 2021·Journal of Reproductive Immunology·Karen Sánchez-LuquezVanusa Pousada da Hora
Jul 6, 2021·Frontiers in Cellular and Infection Microbiology·Luiz Carlos De MattosCinara Cássia Brandão
Jul 10, 2021·Ocular Immunology and Inflammation·Dimitrios KalogeropoulosAlejandra de-la-Torre

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