Genetic analyses of integrin function in mice

Current Opinion in Cell Biology
R FässlerE Hirsch

Abstract

Recent mutations of most integrin genes in the mouse have provided new exciting insights into the role of these integrins in cell-extracellular matrix interactions during development. The embryonic lethal phenotypes obtained by ablating integrins which are predominantly expressed in the mesenchyme confirmed the essential function of those integrins in morphogenesis. In contrast, null alleles for several epithelial integrins which bind components of basement membranes showed milder phenotypes, suggesting the presence of novel and unexpected redundant and compensatory mechanisms.

References

Oct 1, 1992·Current Opinion in Cell Biology·D F MosherJ A McDonald
Jan 1, 1986·The Journal of Immunology : Official Journal of the American Association of Immunologists·T A SpringerD C Anderson
Jan 1, 1987·Annual Review of Medicine·D C Anderson, T A Springer
Sep 1, 1995·Trends in Genetics : TIG·E Dzierzak, A Medvinsky
Dec 1, 1995·Science·M FriedlanderD A Cheresh
Apr 22, 1994·Science·P C BrooksD A Cheresh
Aug 1, 1995·Genes & Development·R Fässler, M Meyer
Aug 1, 1994·Trends in Genetics : TIG·B G Herrmann, A Kispert
Jul 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M Bronner-Fraser
May 20, 1994·Cell·E Ruoslahti, J C Reed
Sep 1, 1993·Molecular Biology of the Cell·J E MeredithM A Schwartz
Jan 1, 1994·Genes & Development·S TakadaA P McMahon
Jan 1, 1996·The Journal of Cell Biology·K WennerbergR Fässler
Jul 1, 1996·Nature Genetics·R van der NeutA Sonnenberg
Jul 1, 1996·Nature Genetics·E Georges-LabouesseM Le Meur
Oct 1, 1996·Developmental Dynamics : an Official Publication of the American Association of Anatomists·E N Georges-LabouesseR O Hynes

❮ Previous
Next ❯

Citations

Jan 1, 1997·Developmental Genetics·J L RinkenbergerZ Werb
Oct 31, 2000·Microscopy Research and Technique·J StutzmannP Simon-Assmann
Aug 3, 2001·Cell Biology International·S Reber-MüllerV Schmid
Mar 1, 2005·Journal of Molecular and Cellular Cardiology·Hossein BaharvandSaeid Kazemi Ashtiani
Aug 19, 2003·Tissue & Cell·K V R Reddy, Sachin S Mangale
Jun 4, 1998·Thrombosis Research·K T Preissner, D Seiffert
Mar 24, 1999·Trends in Neurosciences·J J ArchelosH P Hartung
Sep 6, 2000·Trends in Genetics : TIG·A De Arcangelis, E Georges-Labouesse
Mar 14, 2000·Current Opinion in Cell Biology·S Dedhar
May 6, 1998·Current Opinion in Neurobiology·D Van Vactor
Jun 1, 1997·Trends in Cell Biology·D BiglerJ M White
Mar 18, 2000·Proceedings of the Society for Experimental Biology and Medicine·J A Bowen, J S Hunt
Oct 13, 2001·Molecular Biology of the Cell·S F RettaG Tarone
Dec 17, 1997·Molecular Biology of the Cell·J L SechlerJ E Schwarzbauer
Jan 23, 1999·Current Opinion in Hematology·S Dedhar
Jul 31, 1998·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M KedingerP Simon-Assmann
Jan 26, 1999·Annals of the New York Academy of Sciences·S MiyamotoK M Yamada
Oct 23, 2003·Annual Review of Cell and Developmental Biology·Filippo G Giancotti, Guido Tarone
Sep 24, 2011·Journal of Oncology·Stephan Niland, Johannes A Eble
Oct 31, 2013·BMC Developmental Biology·Robert MooreXiang-Xi Xu
Apr 9, 2002·Cell Structure and Function·Motoko ShibanumaKiyoshi Nose
Dec 30, 2011·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Kalliopi LiadakiLouis M Kunkel
Feb 3, 1999·Annals of the New York Academy of Sciences·P Simon-AssmannA De Arcangelis
Jan 5, 2002·Differentiation; Research in Biological Diversity·J Czyz, A Wobus
Jun 25, 1998·Cell Adhesion and Communication·S T RyanP J Gotwals
Nov 3, 2009·Developmental Biology·Alexander D PerkinsGuy Tanentzapf
Mar 24, 1999·Molecular Membrane Biology·C D BuckleyD L Simmons
Oct 20, 1999·Developmental Biology·T C KlinowskaC H Streuli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.