Genetic analysis and biological characteristics of different internal gene origin H5N6 reassortment avian influenza virus in China in 2016

Veterinary Microbiology
Wenqiang SunXiufan Liu

Abstract

Clade 2.3.4.4 of H5N6 subtype Avian Influenza Viruses (AIVs) has become dominant clade in South-East Asia. So far, a total of 16 cases of human infection, including 6 deaths, have been confirmed since 2014. In this study, we systematically investigated the genetic evolution and biological characteristics of these viruses. We first carried out phylogenetic and statistical analysis of all H5N6 viruses that were downloaded from Influenza Research Database, GISAID and isolates from our lab. We found that H5N6 AIVs continued to reassort with other AIVs subtypes since 2014. Among these H5N6 reassortments, four main gene types were identified: A (internal genes of H5N1-origin), B (PB2 of H6-origin, and others of H5N1-origin), C (internal genes of H9-origin) and D (PB2 of H6-origin and PB1of H3-origin, and others of H5N1). In addition, after several years of evolution, gene type D is currently the dominant gene type. To systematically compare the genetic and evolutionary characteristics and pathogenicity of these viruses, four H5N6 AIVs of different gene types were selected for further analysis. S4, XZ6, GD1602 and YZ587 virus represented gene type A, B, C and D, respectively. Their NA genes were all originated from H6 and their whole ...Continue Reading

Citations

Mar 7, 2020·Reviews in Medical Virology·Reina YamajiWenqing Zhang
Sep 27, 2018·EFSA Journal·UNKNOWN European Food Safety AuthorityFrancesca Baldinelli
Apr 6, 2020·Transboundary and Emerging Diseases·Li-Ling ChenChangjun Bao
Aug 9, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Fan YangHaibo Wu

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