Genetic analysis of APOAV polymorphisms (T-1131/C, Ser19/Trp and Val153/Met): no effect on plasma remnant particles concentrations

Clinica Chimica Acta; International Journal of Clinical Chemistry
Jaroslav A HubacekRudolf Poledne

Abstract

APOAV is newly described protein, which plays a crucial role in the determination of plasma triglyceride (TG) levels. Remnant lipoproteins (RLPs) result from partial catabolised TG-rich particles. Elevated levels of RLP are associated with atherosclerosis, and they are a predictor of coronary events in patients with coronary artery disease. We have evaluated the influence of APOAV polymorphisms (T-1131/C, Ser19/Trp and Val153/Met were measured by PCR and restriction analysis) on plasma levels of RLP-cholesterol and RLP-TG in 285 unrelated representative selected individuals (131 men and 154 women) aged 33-72 years. RLP-cholesterol and RLP-TG levels were not significantly influenced by the APOAV variants either in whole population or in males and females, if analyzed separately. We conclude that variations T-1131/C, Ser19/Trp and Val153/Met in the APOAV gene have no effect on plasma levels of remnant particles.

References

Dec 31, 1993·Clinica Chimica Acta; International Journal of Clinical Chemistry·K NakajimaE Campos
Apr 20, 2001·Clinical Biochemistry·J A HubacekP J Talmud
Nov 6, 2002·Human Molecular Genetics·Len A PennacchioJonathan C Cohen
Nov 6, 2002·Human Molecular Genetics·Philippa J TalmudSteve E Humphries
Aug 14, 2003·Human Molecular Genetics·Jau-Tsuen KaoShu-Wha Lin
Aug 16, 2003·Journal of Medical Genetics·M VrablíkJ A Hubacek

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