Genetic Analysis of Association Between Calcium Signaling and Hippocampal Activation, Memory Performance in the Young and Old, and Risk for Sporadic Alzheimer Disease

JAMA Psychiatry
Angela HeckAndreas Papassotiropoulos

Abstract

Human episodic memory performance is linked to the function of specific brain regions, including the hippocampus; declines as a result of increasing age; and is markedly disturbed in Alzheimer disease (AD), an age-associated neurodegenerative disorder that primarily affects the hippocampus. Exploring the molecular underpinnings of human episodic memory is key to the understanding of hippocampus-dependent cognitive physiology and pathophysiology. To determine whether biologically defined groups of genes are enriched in episodic memory performance across age, memory encoding-related brain activity, and AD. In this multicenter collaborative study, which began in August 2008 and is ongoing, gene set enrichment analysis was done by using primary and meta-analysis data from 57 968 participants. The Swiss cohorts consisted of 3043 healthy young adults assessed for episodic memory performance. In a subgroup (n = 1119) of one of these cohorts, functional magnetic resonance imaging was used to identify gene set-dependent differences in brain activity related to episodic memory. The German Study on Aging, Cognition, and Dementia in Primary Care Patients cohort consisted of 763 elderly participants without dementia who were assessed for ep...Continue Reading

Citations

Mar 17, 2016·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Oliver PetersWolfgang Maier
Mar 20, 2016·Schizophrenia Bulletin·Aiden Corvin, Patrick F Sullivan
Apr 26, 2016·Annals of the New York Academy of Sciences·Paul J HarrisonJohn R Geddes
Apr 27, 2017·Nature Communications·Virginie FreytagAndreas Papassotiropoulos
Aug 21, 2020·Proceedings of the National Academy of Sciences of the United States of America·Vanja VukojevicDominique J-F de Quervain
Jul 22, 2017·Brain and Behavior·David CoynelDominique J-F de Quervain
Jun 22, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Weiwei ZhongShan Ping Yu

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