Genetic analysis of cover test measures and AC/A ratio in human populations with varying incidences of strabismus.

The British Journal of Ophthalmology
A J MashB E Spivey

Abstract

The genetic analyses of indices relating to distance alignment and accommodative convergence are presented. This approach is important in understanding the contribution of genetic factors to observed individual differences for these measures. Abnormalities of either of these two components results in a tendency towards either a convergent or divergent position of the eyes (relative to the position of fusional demand) and thus places an additional load or strain on the other components of the binocular mechanism which must compensate for this potential disruption. If compensation is inadequate to maintain alignment of the eyes, a manifest deviation will result. Consequently, an understanding of the aetiology of such factors underlies an understanding of the aetiology of nonparalytic strabismus. The three populations displayed different tendencies in the cover test measure. The average tendency for each of the populations was consistent with the type of deviation common to all propositi of families within each of the respective populations. The heritability of this character was similar in the three populations and was dependent on the contribution of the female parent only, but to a substantial degree (h2 = 0-42 +/- 0-12). The n...Continue Reading

References

Mar 1, 1972·Archives of Ophthalmology·D SmithB Spivey

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Citations

Sep 1, 1979·American Journal of Ophthalmology·B E SpiveyJ P Hegmann
Mar 1, 1994·Ophthalmic Genetics·T O Paul, L K Hardage
Sep 21, 2010·Survey of Ophthalmology·Paul G SanfilippoDavid A Mackey
Feb 1, 1980·Australian Journal of Ophthalmology·B E Spivey
Aug 15, 2009·Vision Research·Jeremy B Wilmer, Benjamin T Backus
Nov 24, 2004·Progress in Retinal and Eye Research·Ian Morgan, Kathryn Rose
Aug 1, 1980·Vox Sanguinis·A E von dem BorneL E Nijenhuis
Jan 1, 1977·European Journal of Clinical Pharmacology·N P Boye, J R Vale

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