Genetic analysis of ESCRT function in Drosophila: a tumour model for human Tsg101.

Biochemical Society Transactions
Hans-Martin Herz, Andreas Bergmann

Abstract

Class E Vps (vacuolar protein sorting) proteins are components of the ESCRTs (endosomal sorting complexes required for transport) which are required for protein sorting at the early endosome. Most of these genes have been identified and genetically characterized in yeast. Recent genetic studies in Drosophila have revealed the phenotypic consequences of loss of vps function in multicellular organisms. In the present paper, we review these studies and discuss a mechanism which may explain how loss of the human Tsg101 (tumour susceptibility gene 101), a vps23 orthologue, causes tumours.

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Citations

Jun 9, 2012·PloS One·Hillary K GravesAndreas Bergmann
Apr 2, 2014·Seminars in Cell & Developmental Biology·Marc AmoyelErika A Bach
Oct 8, 2011·Expert Opinion on Therapeutic Targets·Barbara Belletti, Gustavo Baldassarre
Jul 7, 2011·Developmental Biology·Gina LeeJongkyeong Chung
Sep 19, 2014·Stem Cells Translational Medicine·Indrayani WaghmareIchiro Nakano
Jun 13, 2018·International Journal of Molecular Sciences·Sarah E VandalS Tariq Ahmad

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