PMID: 8595851Jan 15, 1996Paper

Genetic analysis of exoenzyme S expression by Pseudomonas aeruginosa

FEMS Microbiology Letters
J Goranson, D W Frank

Abstract

The dissemination of Pseudomonas aeruginosa to the bloodstream increases the likelihood of developing fatal sepsis. In experimental models, the ability to disseminate is linked to expression of the exoenzyme S pathway. Genetic and biochemical analysis of the pathway has led to the identification of the two structural genes encoding exoenzyme S, exoS and exoT. A key regulator of several loci of the pathway has been identified as a DNA-binding protein with transcriptional activation properties. Preliminary evidence suggests that exoenzyme S and the Yop virulence determinants of yersiniae share homology among proteins involved in their synthesis and secretion. With the addition of exoS and exoT to the molecular arsenal, questions concerning in vivo toxicity and target specificities of exoenzyme S can be directly addressed.

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Citations

Mar 12, 2004·Annual Review of Phytopathology·S Y He
May 8, 2003·Journal of Clinical Microbiology·Karine FaureJeanine P Wiener-Kronish
Aug 5, 2004·Journal of Bacteriology·Peter BurghoutMargot Koster
Jun 20, 2015·PLoS Pathogens·Stephanie M RangelAlan R Hauser
Apr 27, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kiyoyasu KurahashiYoshitsugu Yamada
Feb 13, 2015·Critical Care : the Official Journal of the Critical Care Forum·Teiji SawaJeanine P Wiener-Kronish
Feb 20, 1999·Infection and Immunity·J RadkeJ T Barbieri
Mar 17, 2004·Biochemical and Biophysical Research Communications·Miki TamuraTeiji Sawa

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