Genetic analysis of FMR1 repeat expansion in essential tremor

Neuroscience Letters
L N ClarkElan D Louis

Abstract

We performed an association analysis of Fragile X mental retardation 1 (FMR1) CGG repeats in 321 essential tremor (ET) cases and 296 controls at Columbia University. In addition to analyzing the allele distribution (10-49 CGG repeats) in the entire sample, we also performed a screen for ET cases with the FMR1 premutation allele (55-200 CGG repeats), and evaluated an association between ET and FMR1 alleles that included gray zone alleles (41-54 CGG repeats). CGG premutation alleles and gray zone alleles were rare in ET cases, and we found no evidence for association of premutation or gray zone alleles with ET. These data suggest that FMR1 CGG repeats are not a genetic risk factor for ET.

References

Oct 14, 2004·JAMA : the Journal of the American Medical Association·Hao DengJoseph Jankovic
Feb 23, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Elan D Louis, Joaquim J Ferreira
Apr 8, 2010·European Journal of Human Genetics : EJHG·Lorraine N ClarkElan D Louis
Oct 19, 2012·Neurology·Emmanuelle ApartisMathieu Anheim
Mar 26, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·E D LouisM Galecki
May 31, 2014·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Karin WeissShay Ben-Shachar

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Citations

Jul 16, 2016·The Clinical Neuropsychologist·Erin E RobertsonJoan A O'Keefe
Apr 1, 2018·Clinical Genetics·M I Alvarez-MoraM Milà
Jul 4, 2019·Journal of Medical Systems·Jeya Bharathi S, Balamanikandan P
Jan 13, 2018·Der Nervenarzt·G Kuhlenbäumer, F Hopfner
Jun 25, 2020·International Journal of Molecular Sciences·Ana Maria Cabal-HerreraRandi J Hagerman
Jun 3, 2021·Pharmaceuticals·Félix Javier Jiménez-JiménezJosé A G Agúndez

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