PMID: 6988707Mar 1, 1980Paper

Genetic analysis of gamma-ray mutagenesis in yeast. III. Double-mutant strains

Mutation Research
R H McKee, C W Lawrence

Abstract

Comparisons between the 60Co gamma-ray survival curves of diploid strains of the yeast Saccharomyces cerevisiae that are homozygous for two non-allelic radiation-sensitive mutations and the corresponding single-mutant diploids suggest that there are two main types of repair of ionizing radiation damage in this organism. The first, which is defined by the rad52 epistasis group, depends on the activities of the RAD50 through RAD57 genes and is responsible for repairing the larger amount of lethal damage. Previous work [22] shows that this type of repair is essentially error-free. The second, defined by the rad6 epistasis group, depends on the activities of the RAD6, RAD9, RAD18, REV1 and REV3 genes and repairs a smaller, though still substantial, amount of lethal damage. It is also responsible for induced mutagenesis [22, 23]. Data for survival and mutation induction after irradiation in air and partial anoxia show that oxygen-dependent damage can be repaired by either of these two pathways. They also show similar oxygen-enhancement ratios for survival and mutagenesis.

Citations

Jan 1, 1981·Molecular & General Genetics : MGG·V G Petin, V L Matrenina
Dec 1, 1990·Current Genetics·J A Henriques, M Brendel
Aug 1, 2000·Mutation Research·J C Game
Dec 6, 2001·Cancer Letters·Manfred SchwabLarissa Savelyeva
Oct 11, 2002·The EMBO Journal·Yukiko M YamashitaShunichi Takeda
Oct 24, 2006·Genetics·Leslie BarbourWei Xiao
Nov 1, 1993·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·V V DeorukhakarB S Rao
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Feb 24, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C W Lawrence, V M Maher
Nov 1, 1982·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·V G Petin, V I Ryabchenko
Mar 31, 2018·The Journal of Biological Chemistry·William Douglass WrightWolf-Dietrich Heyer

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