Genetic analysis of human H2N2 and early H3N2 influenza viruses, 1957-1972: evidence for genetic divergence and multiple reassortment events

Virology
Stephen LindstromA Klimov

Abstract

Phylogenic analysis of all gene segments of human H2N2 viruses isolated from 1957 to 1968 was undertaken to better understand the evolution of this virus subtype. Human H3N2 viruses isolated from 1968 to 1972 were also examined to investigate genetic events associated with their emergence in humans and to identify the putative H2N2 ancestral virus. All gene segments of human H2N2 viruses demonstrated divergent evolution into two distinct clades (I and II) among late H2N2 isolates. All gene segments of 1968 H3N2 viruses that were retained from human H2N2 viruses were most similar to clade I H2N2 genes. However, genes of both clades were found among H3N2 isolates of 1969-1971. Unique phylogenic topologies reflected multiple reassortment events among late H2N2 or H3N2 viruses that resulted in a variety of different genome constellations. These results suggest that H2N2 viruses continued to circulate after 1968 and that establishment of H3N2 viruses in humans was associated with multiple reassortment events that contributed to their genetic diversity.

References

Feb 1, 1992·The Journal of General Virology·Y J GuoN J Cox
Apr 11, 1989·Nucleic Acids Research·S L Zebedee, R A Lamb
Jan 1, 1981·Journal of Molecular Evolution·J Felsenstein
Apr 17, 1980·Nature·W J BeanA P Kendal
Jul 22, 1997·Proceedings of the National Academy of Sciences of the United States of America·W M FitchN J Cox
Sep 20, 2001·The Journal of General Virology·E TsuchiyaK Nakamura
May 3, 2002·Reviews in Medical Virology·Ralf WagnerHans-Dieter Klenk

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Citations

Jan 12, 2007·PLoS Medicine·Christina E MillsMarc Lipsitch
Sep 12, 2013·Future Microbiology·Mohamed E El ZowalatyHossam M Ashour
Jan 25, 2014·BMC Evolutionary Biology·Lu LuAndrew J Leigh Brown
Dec 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Olin K SilanderLin Chao
Aug 5, 2014·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Tadanobu Takahashi
Aug 17, 2005·Journal of Virology·E G M BerkhoffG F Rimmelzwaan
Oct 6, 2006·Journal of Clinical Microbiology·Annie MakMartin Petric
Dec 5, 2006·PLoS Pathogens·Martha I NelsonEdward C Holmes
Jul 24, 2008·Proceedings. Biological Sciences·Sergey KryazhimskiyJonathan Dushoff
Sep 6, 2008·Microbiology and Molecular Biology Reviews : MMBR·Colin R ParrishPeter Daszak
Jun 26, 2009·Journal of Virology·Elodie GhedinDavid J Spiro
Oct 8, 2009·PloS One·Hossein KhiabanianRaul Rabadan
Feb 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Chengjun LiYoshihiro Kawaoka
Sep 30, 2010·MBio·David M MorensAnthony S Fauci
Dec 3, 2010·PLoS Computational Biology·Joseph ChanRaul Rabadan
Jul 5, 2011·Nature Reviews. Microbiology·Etienne Simon-Loriere, Edward C Holmes
Oct 26, 2011·BMC Genomics·Alisa Yurovsky, Bernard M E Moret
Mar 6, 2013·The American Journal of Tropical Medicine and Hygiene·Janet MajanjaWallace Bulimo
Feb 7, 2014·Journal of Virology·Guojun WangHualan Chen
Dec 27, 2005·The Pediatric Infectious Disease Journal·Thomas A Reichert
Mar 16, 2011·Yi chuan = Hereditas·Chang-Zheng Dong
Dec 14, 2012·BMC Medicine·Tom ReichertJonathan A McCullers
Feb 22, 2011·The European Physical Journal. E, Soft Matter·A Fierro, A Liccardo
Jun 5, 2013·Indian Journal of Virology : an Official Organ of Indian Virological Society·Madhu KhannaPrashant Kumar
Sep 13, 2005·Annual Review of Microbiology·Colin R Parrish, Yoshihiro Kawaoka
Feb 5, 2011·Emerging Infectious Diseases·Eefje J A SchrauwenRon A M Fouchier
Jun 2, 2015·Biological & Pharmaceutical Bulletin·Tadanobu Takahashi, Takashi Suzuki
Sep 11, 2012·Archives of Medical Research·Luis M TeranThomas Franz
Apr 3, 2012·Comptes rendus biologies·Jan P Radomski, Piotr P Slonimski
Oct 23, 2010·American Journal of Preventive Medicine·Bruce Y LeeDonald S Burke
Jan 21, 2015·Scientific Reports·Chiara PolettoAlessandro Vespignani
Jan 1, 2008·Influenza and Other Respiratory Viruses·Raul RabadanMichael Krasnitz
Jan 26, 2011·Journal of Medical Virology·Karen Ka Yin WongWilliam Rawlinson
Jun 29, 2011·Microbiology and Immunology·Masaoki YamaokaYoshihiro Kawaoka
Aug 30, 2008·Virology·Cheng-Qiang HeNai-Zheng Ding

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