Genetic analysis of low BMI phenotype in the Utah Population Database

PloS One
William R YatesLisa A Cannon-Albright

Abstract

The low body mass index (BMI) phenotype of less than 18.5 has been linked to medical and psychological morbidity as well as increased mortality risk. Although genetic factors have been shown to influence BMI across the entire BMI, the contribution of genetic factors to the low BMI phenotype is unclear. We hypothesized genetic factors would contribute to risk of a low BMI phenotype. To test this hypothesis, we conducted a genealogy data analysis using height and weight measurements from driver's license data from the Utah Population Data Base. The Genealogical Index of Familiality (GIF) test and relative risk in relatives were used to examine evidence for excess relatedness among individuals with the low BMI phenotype. The overall GIF test for excess relatedness in the low BMI phenotype showed a significant excess over expected (GIF 4.47 for all cases versus 4.10 for controls, overall empirical p-value<0.001). The significant excess relatedness was still observed when close relationships were ignored, supporting a specific genetic contribution rather than only a family environmental effect. This study supports a specific genetic contribution in the risk for the low BMI phenotype. Better understanding of the genetic contribution ...Continue Reading

References

Nov 13, 1992·Science·L A Cannon-AlbrightA E Bale
May 24, 1990·The New England Journal of Medicine·A J StunkardG E McClearn
Jan 1, 1989·Neuroscience and Biobehavioral Reviews·P R Costanzo, S S Schiffman
Jan 1, 1986·Genetic Epidemiology. Supplement·L A CannonM H Skolnick
Mar 1, 1996·Nature Genetics·S V TavtigianD E Goldgar
Nov 1, 1995·Obesity Research·H R Rony
Mar 20, 2001·American Journal of Human Genetics·D VespriniS A Narod
Aug 21, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·P K E Magnusson, F Rasmussen
Apr 21, 2005·JAMA : the Journal of the American Medical Association·Katherine M FlegalMitchell H Gail
Jul 13, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·John Scott MaulLisa A Cannon-Albright
Aug 11, 2007·American Journal of Respiratory and Critical Care Medicine·Craig C TeerlinkLisa A Cannon-Albright
Dec 7, 2007·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·M B WeiresL A Cannon-Albright
Dec 13, 2007·Human Heredity·Lisa A Cannon Albright
Jan 4, 2008·The Journal of Infectious Diseases·Frederick S AlbrightLisa A Cannon Albright
Feb 2, 2008·Obesity·Steven C HuntTed D Adams
Mar 10, 2009·American Journal of Human Genetics·Xiao-Gang LiuHong-Wen Deng
May 5, 2009·The Journal of Bone and Joint Surgery. American Volume·Robert Z TashjianLisa A Cannon-Albright
Jun 17, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Hamisu M SalihuPhillip J Marty
Jun 23, 2009·European Journal of Medical Research·P KalkB Hocher
Jul 18, 2009·American Journal of Respiratory and Critical Care Medicine·David J LedererSelim M Arcasoy
Aug 5, 2009·European Journal of Epidemiology·A S Khashan, L C Kenny
Sep 29, 2009·American Journal of Perinatology·Aaron B DeutschWilliam N Spellacy
Jan 23, 2010·Metabolism: Clinical and Experimental·Jessica BahElias Eriksson
Jun 24, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Brian H ShirtsLisa A Cannon-Albright
Nov 8, 2011·Journal of Nutrigenetics and Nutrigenomics·Felix R Day, Ruth J F Loos
Jan 25, 2014·American Journal of Medical Genetics. Part a·Hussam Al-KatebMarwan Shinawi

❮ Previous
Next ❯

Citations

Jul 18, 2020·Genetic Epidemiology·Heather M Ochs-BalcomLisa A Cannon-Albright
Jul 8, 2018·Journal of Human Genetics·Craig C TeerlinkMichael D Rollins

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.

Related Papers

The Journal of Bone and Joint Surgery. American Volume
Robert Z TashjianLisa A Cannon-Albright
Pituitary
William T Couldwell, Lisa A Cannon-Albright
Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
M B WeiresLisa A Cannon-Albright
Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society
James P LeeLisa A Cannon-Albright
The Journal of Infectious Diseases
Frederick S AlbrightLisa A Cannon Albright
© 2021 Meta ULC. All rights reserved