Genetic analysis of mammographic breast density in adult women: evidence of a gene effect

Journal of the National Cancer Institute
J S PankowThomas A Sellers


The appearance of the female breast viewed by mammography varies considerably from one individual to another because of underlying differences in the relative proportions of fat, connective tissue, and glandular epithelium that combine to create a characteristic pattern of breast density. An association between mammographic patterns and family history of breast cancer has previously been reported. However, this association has not been found in all studies, and few data are available on possible genetic components contributing to mammographic breast density. Our purpose was to estimate familial correlations and perform complex genetic segregation analyses to test the hypothesis that the transmission of a major gene influences mammographic breast density. As part of a cohort study (initiated in 1944) of families with a history of breast cancer, the probands' female relatives who were older than 40 years were asked to obtain a routine mammogram. The mammograms of 1370 women from 258 independent families were analyzed. The fraction of the breast volume occupied by radiographically dense tissue was estimated visually from video displays of left or right mediolateral oblique views by one radiologist experienced in mammography who ha...Continue Reading


Jun 1, 1976·AJR. American Journal of Roentgenology·J N Wolfe
Jun 1, 1978·AJR. American Journal of Roentgenology·S HainlineW Shingleton
Jun 1, 1991·Cancer·A F SaftlasJ N Wolfe
Mar 1, 1989·American Journal of Epidemiology·A F SaftlasM Szklo
Jan 1, 1987·Epidemiologic Reviews·A F Saftlas, M Szklo
Mar 1, 1982·American Journal of Epidemiology·J BrissonF Merletti
Mar 1, 1980·Radiology·V ErnsterR J Schweitzer
Feb 1, 1980·The British Journal of Radiology·I H GravelleJ L Hayward
Dec 1, 1980·Cancer·J N WolfeM Salane
Nov 1, 1995·Journal of the National Cancer Institute·C ByrneR Haile
Jan 1, 1993·Epidemiologic Reviews·A M Oza, Norman F Boyd
May 15, 1996·Journal of the National Cancer Institute·M B LayaE White
Oct 1, 1994·Physics in Medicine and Biology·J W ByngMartin Yaffe


Nov 2, 2005·Breast Cancer Research and Treatment·Jeffrey A TiceKarla Kerlikowske
Mar 30, 2010·Breast Cancer Research and Treatment·Joohon SungSung-Soo Kim
Jul 6, 2001·European Journal of Radiology·Ruth Warren
Nov 5, 2002·Magnetic Resonance Imaging·Ruth WarrenUK MRI breast screening study (MARIBS)
Feb 27, 2003·Breast Cancer Research and Treatment·Christopher A HaimanC Byrne
Sep 21, 2004·Breast Cancer Research and Treatment·G HaarsD E Grobbee
Sep 6, 2008·Nature Reviews. Cancer·Linda E KelemenCeline M Vachon
Dec 7, 2011·Nature Reviews. Clinical Oncology·Valentina AssiStephen W Duffy
Sep 26, 2006·Oncogene·A C Antoniou, Douglas F Easton
May 12, 2001·The Breast Journal·Carol Fabian
Feb 15, 2001·The New England Journal of Medicine·M Clemons, P Goss
Jan 10, 2003·The New England Journal of Medicine·Celine M VachonV Shane Pankratz
Sep 20, 2002·The New England Journal of Medicine·Norman F BoydJohn L Hopper
Apr 26, 2012·Human Molecular Genetics·Kristen N StevensCeline M Vachon
Apr 16, 1997·Journal of the National Cancer Institute·C Byrne
Apr 3, 2003·Journal of the National Cancer Institute·Elad ZivKarla Kerlikowske
Apr 22, 2004·Journal of the National Cancer Institute·Jack CuzickStephen W Duffy
Jul 10, 2010·Journal of the National Cancer Institute·Norman F BoydSalomon Minkin
Nov 26, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Julie A DouglasMark A Helvie
Aug 4, 2011·BMC Cancer·Gertraud MaskarinecRachel Novotny
Jan 15, 2008·Breast Cancer Research : BCR·Celine M VachonV Shane Pankratz
Aug 7, 2008·Breast Cancer Research : BCR·Rulla M TamimiDavid J Hunter
Oct 1, 2010·Annals of Surgical Oncology·Nimmi AroraMonica Morrow
May 20, 1998·American Journal of Public Health·B K Rimer
Mar 13, 2014·Breast Cancer Research and Treatment·C W HuoE W Thompson
Nov 8, 2014·Journal of the National Cancer Institute·Judith S BrandKamila Czene
Nov 13, 2009·Climacteric : the Journal of the International Menopause Society·E H de Moura RamosN Souza
Feb 6, 2010·European Journal of Radiology·C ColinP J Valette
Mar 30, 2016·British Journal of Cancer·D Gareth EvansAnthony Howell
Oct 4, 2005·The Lancet Oncology·Norman F BoydAndrew D Paterson
Aug 2, 2005·Alcohol·Ramona G Dumitrescu, Peter G Shields
Oct 22, 2014·International Journal of Cancer. Journal International Du Cancer·Valentina AssiStephen W Duffy
Aug 23, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Martin YaffeAr Genazzani
Jul 11, 2015·BMC Research Notes·Elizabeth J AtkinsonCeline M Vachon
Jun 19, 2002·Clinical Radiology·Deanne SoaresMichael James
Sep 20, 2001·Seminars in Cancer Biology·J L Hopper
Jul 11, 2015·Breast Cancer Research : BCR·D Gareth Evans, Anthony Howell

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.

Related Papers

The New England Journal of Medicine
Norman F BoydJohn L Hopper
Journal of the National Cancer Institute
Celine M VachonThomas A Sellers
International Journal of Cancer. Journal International Du Cancer
Gertraud MaskarinecLoic Le Marchand
© 2021 Meta ULC. All rights reserved