Sep 19, 2018

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Nature Genetics
Evangelos EvangelouMillion Veteran Program

Abstract

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

Mentioned in this Paper

Genome-Wide Association Study
Biochemical Pathway
Quantitative Trait Loci
Blood Pressure Regulation
Genetic Analysis
Genetic Screening Method
Diastolic Blood Pressure
Genetics, Population
Genetic Association Studies
Persons

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