Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

BioRxiv : the Preprint Server for Biology
Evangelos EvangelouMark J Caulfield

Abstract

High blood pressure is the foremost heritable global risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits to date (systolic, diastolic, pulse pressure) in over one million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also reveal shared loci influencing lifestyle exposures. Our findings offer the potential for a precision medicine strategy for future cardiovascular disease prevention.

Related Concepts

Blood Pressure Regulation
Genetic Analysis
Genetic Screening Method
Genetic Association Studies
Persons
Cardiovascular Diseases
Hypertensive Disease
Pharmaceutical Preparations
Blood Pressure
Diastole

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