Genetic analysis of posterior medial barrel subfield (PMBSF) size in somatosensory cortex (SI) in recombinant inbred strains of mice

BMC Neuroscience
Taha A JanRobert S Waters

Abstract

Quantitative trait locus (QTL) mapping is an important tool for identifying potential candidate genes linked to complex traits. QTL mapping has been used to identify genes associated with cytoarchitecture, cell number, brain size, and brain volume. Previously, QTL mapping was utilized to examine variation of barrel field size in the somatosensory cortex in a limited number of recombinant inbred (RI) strains of mice. In order to further elucidate the underlying natural variation in mouse primary somatosensory cortex, we measured the size of the posterior medial barrel subfield (PMBSF), associated with the representation of the large mystacial vibrissae, in an expanded sample set that included 42 BXD RI strains, two parental strains (C57BL/6J and DBA/2J), and one F1 strain (B6D2F1). Cytochrome oxidase labeling was used to visualize barrels within the PMBSF. We observed a 33% difference between the largest and smallest BXD RI strains with continuous variation in-between. Using QTL linkage analysis from WebQTL, we generated linkage maps of raw total PMBSF and brain weight adjusted total PMBSF areas. After removing the effects of brain weight, we detected a suggestive QTL (likelihood ratio statistic [LRS]: 14.20) on the proximal arm...Continue Reading

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Citations

Jun 23, 2009·Current Opinion in Neurology·Alexandra BadeaRobert W Williams
Jan 1, 2014·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Robert HitzemannShannon McWeeney
Jun 6, 2008·Current Opinion in Neurobiology·Dennis Dm O'Leary, Setsuko Sahara
Apr 6, 2016·NeuroImage·Jan ScholzMark Henkelman
Apr 17, 2013·NeuroImage·Jeremy F P UllmannDavid C Reutens

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Methods Mentioned

BETA
GTPase

Software Mentioned

Excel
WebQTL
Data Desk
GeneNetwork
Allen Brain Atlas
ImageJ
Adobe Photoshop

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