PMID: 9529614Apr 8, 1998Paper

Genetic analysis of protein tyrosine phosphatases

Current Opinion in Genetics & Development
D Van VactorB G Neel

Abstract

Genetic analysis has enhanced our understanding of the biological roles of many protein tyrosine kinases (PTKs). More recently, studies utilizing both spontaneous mutants and mutants induced by homologous recombination techniques have begun to yield key insights into the role of specific protein tyrosine phosphatases (PTPs) and to suggest how PTKs and PTPs interact. Specific PTPs in Saccharomyces cerevesiae and Schizomyces pombe regulate MAP kinase pathways. Several Drosophila receptor PTPs control axonal targeting pathways, whereas the non-receptor PTP Corkscrew (Csw), plays an essential positive signaling role in multiple developmental pathways directed by receptor PTKs. The vertebrate homolog of Csw, SHP-2, also is required for growth factor signaling and normal development. Finally, very recent studies of other mammalian PTPs suggest that they have critical roles in processes as diverse as hematopoiesis and liver and pituitary development.

References

Dec 2, 1994·Science·K Vuori, E Ruoslahti
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·K YamauchiJ E Pessin
Jun 1, 1995·The Journal of Cell Biology·C C MastickA R Saltiel
Sep 22, 1995·The Journal of Biological Chemistry·R A Klinghoffer, A Kazlauskas
Nov 1, 1995·The Journal of Cell Biology·S MiyamotoK M Yamada
Jul 28, 1995·The Journal of Biological Chemistry·K YamauchiJ E Pessin
Aug 1, 1995·The Journal of Cell Biology·S M Brady-KalnayN K Tonks
Mar 12, 1993·Cell·Z SongyangR J Lechleider
Apr 1, 1994·Current Opinion in Cell Biology·N Perrimon
Apr 1, 1994·Molecular Biology of the Cell·L S HuangP W Sternberg
Feb 1, 1994·Trends in Genetics : TIG·G S Feng, T Pawson
Oct 22, 1993·Science·I M Ota, A Varshavsky
Dec 1, 1993·Seminars in Cell Biology·B G Neel
Feb 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D PeiC T Walsh
Jun 18, 1993·Cell·D V VactorC S Goodman
Oct 1, 1995·Current Opinion in Cell Biology·S M Brady-Kalnay, N K Tonks
Feb 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·L B Rosen, M E Greenberg

❮ Previous
Next ❯

Citations

Feb 21, 2008·Cancer Metastasis Reviews·Gordon ChanBenjamin G Neel
Jun 12, 2003·Metabolism: Clinical and Experimental·Jason C O'Connor, Gregory G Freund
Nov 7, 1998·Biochimica Et Biophysica Acta·D A Carter
Oct 11, 2002·Free Radical Biology & Medicine·Kyoungmun Lee, Walter J Esselman
Jul 23, 1999·Mechanisms of Development·J den Hertog
Mar 15, 2001·Current Opinion in Cell Biology·N K Tonks, B G Neel
Apr 30, 1998·Current Opinion in Cell Biology·D Van Vactor
May 6, 1998·Current Opinion in Neurobiology·D Van Vactor
Oct 6, 1999·Current Opinion in Neurobiology·A Chisholm, M Tessier-Lavigne
May 18, 2001·Trends in Cell Biology·A Ostman, F D Böhmer
Jun 27, 2003·Trends in Biochemical Sciences·Benjamin G NeelLily Pao
Feb 22, 2003·Molecular and Cellular Neurosciences·Gustavo Sajnani-PerezAndrew W Stoker
Jul 27, 2001·Current Opinion in Chemical Biology·Z Y Zhang
Sep 3, 2004·Nature Reviews. Cancer·Masanori Hatakeyama
Aug 1, 2002·The Plant Journal : for Cell and Molecular Biology·Anthony P Fordham-SkeltonJohn A Gatehouse
Feb 16, 2002·The EMBO Journal·Christophe BlanchetotJeroen den Hertog
Nov 16, 2004·Journal of Virology·Bertille ProvostJean-Michel Drezen
Apr 29, 2009·Molecular and Cellular Biology·Hsueh-Yen KuTzu-Ching Meng
Dec 14, 1999·Molecular and Cellular Biology·A M O'ReillyB G Neel
Sep 13, 2000·Molecular and Cellular Biology·H GuB G Neel
Feb 28, 2002·Annual Review of Immunology·André VeilletteDominique Davidson
Jan 25, 2002·Annual Review of Pharmacology and Toxicology·Zhong-Yin Zhang
Feb 6, 2002·The Journal of Clinical Investigation·Kenneth A Frauwirth, Craig B Thompson
Dec 12, 2012·Journal of Biomedical Science·Shu-Fen ChenSeng-Sheen Fan
Oct 12, 2007·Development·Yvette G LangdonFrank L Conlon
Jan 27, 2012·Development·Yvette LangdonFrank L Conlon
Apr 20, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Meng QianYi Zhong
Mar 20, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zhigang CaiXin Zhang
Feb 25, 2014·Developmental and Comparative Immunology·Zakia KanwalHerman P Spaink
Apr 17, 2002·The Journal of Cell Biology·Rosa Ana LacalleSantos Manes
Nov 29, 2011·Brain & Development·Yuahn-Sieh HuangKuo-Hsing Ma
May 4, 2011·Birth Defects Research. Part A, Clinical and Molecular Teratology·Erin KaltenbrunFrank L Conlon
Feb 9, 2010·Cell Biology International·Sakiko MiyazuMamoru Nakanishi
Mar 5, 2003·Immunological Reviews·Lisa A PitcherNicolai S C van Oers
Sep 27, 2014·Seminars in Cell & Developmental Biology·Jessica LauriolMaria I Kontaridis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved