Genetic analysis of simulated oligogenic traits in nuclear and extended pedigrees: summary of GAW10 contributions

Genetic Epidemiology
E M Wijsman, C I Amos

Abstract

Participants of GAW10 had available simulated data on phenotypic and marker data for 200 replicates of each of two different collections of pedigrees. The simulated phenotype was multivariate and oligogenic, and included a number of complexities. Participants took widely different approaches to analysis. We compare their results to identify analysis approaches and use of the data that had the greatest impact on the conclusions, accuracy of estimates, and power to identify genetic factors.

References

Jan 1, 1985·Genetic Epidemiology·W C Blackwelder, R C Elston
Mar 1, 1972·Behavior Genetics·J K Haseman, R C Elston
Jul 1, 1995·Annals of Human Genetics·P C Sham, D Curtis
Mar 17, 1995·Science·A Lawler

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Citations

Feb 4, 2010·Archives of General Psychiatry·David C GlahnMichael A Escamilla
Feb 21, 1997·American Journal of Medical Genetics·K K Kidd
Dec 22, 1999·Genetic Epidemiology·E W DawE M Wijsman
Jan 19, 2000·European Child & Adolescent Psychiatry·J Gayán, R K Olson
Nov 15, 2006·Human Genetics·Bradley T WebbSreekumar G Pillai
Feb 1, 2005·Journal of Human Genetics·Alka MalhotraSandra J Hasstedt
Sep 1, 2005·Current Osteoporosis Reports·Joseph M ZmudaSusan P Moffett
Aug 2, 2006·Molecular Psychiatry·G D SchellenbergE M Wijsman
Jan 19, 2006·Journal of the National Cancer Institute·Maja ZecevicMarsha L Frazier
May 23, 2008·Annals of Human Genetics·E W DawS Shete
Feb 7, 2007·Human Heredity·Yun Ju Sung, Ellen M Wijsman
Jun 17, 2010·Human Heredity·Jianzhong MaChristopher I Amos
Mar 1, 2012·BMC Proceedings·Mengdie Yuan, Guoqing Diao
Sep 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D KarasikD P Kiel
Jan 24, 2012·Genetics·Sharon R Browning, Elizabeth A Thompson
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Dvora ShmulewitzJeffrey M Friedman
Dec 16, 2004·Annals of Human Genetics·J T Williams, J Blangero
Jan 15, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·M Ryan DicksonRodney C P Go
Sep 12, 2008·Clinical Genetics·C M Stein, R C Elston
May 9, 2014·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Kevin B RubensteinEllen M Wijsman
Jul 16, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Eun-Jeong JooJohn R Kelsoe
Mar 25, 2010·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Elizabeth E MarchaniEllen M Wijsman

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