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Genetic Analysis of Substrain Divergence in NOD Mice

bioRxiv

Dec 20, 2014

Petr SimecekEdward H Leiter

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Abstract

The NOD mouse is a polygenic model for type 1 diabetes that is characterized by insulitis, a leukocytic infiltration of the pancreatic islets. During ~35 years since the original inbred strain was developed in Japan, NOD substrains have been established at different laboratories around ...read more

Mentioned in this Paper

Genetic Analysis
Diabetes
Array
Genetic Screening Method
Leucocytic Infiltrate
Single Nucleotide Polymorphism
Mice, Inbred NOD
Inbred Strain
Genome
Genetic Drift
4
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  • Genetic Analysis of Substrain Divergence in NOD Mice

    bioRxiv

    Dec 20, 2014

    Petr SimecekEdward H Leiter

    PMID: 990013037

    DOI: 10.1101/013037

    Abstract

    The NOD mouse is a polygenic model for type 1 diabetes that is characterized by insulitis, a leukocytic infiltration of the pancreatic islets. During ~35 years since the original inbred strain was developed in Japan, NOD substrains have been established at different laboratories around ...read more

    Mentioned in this Paper

    Genetic Analysis
    Diabetes
    Array
    Genetic Screening Method
    Leucocytic Infiltrate
    4
    Paper Details
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