Genetic analysis of the actin cytoskeleton in the Drosophila ovary

Annual Review of Cell and Developmental Biology
D N Robinson, L Cooley

Abstract

The Drosophila ovary provides a favorable model system in which to study cellular morphogenesis. The development of a mature egg involves a syncytium of 16 germline cells and over 1000 somatically derived follicle cells. Intercellular transport, stable intercellular bridges, cell migrations, cell shape changes, and specific subcellular localization of many embryonic patterning determinants contribute to egg development and require a dynamic cytoskeleton. We discuss many of the recent genetic and cell biological studies that have led to insights into how the actin cytoskeleton is assembled and regulated during the morphogenesis of the Drosophila egg.

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Methods Mentioned

BETA
electron microscopy
nucleotide exchange
two-hybrid
GTPases
transgenic

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