Genetic analysis of the cause of gastroschisis in the HLG mouse strain

Mutation Research
S HillebrandtW U Müller

Abstract

An inbred mouse strain HLG shows a high incidence of gastroschisis after X-ray exposure to the zygotes. About 11% of the fetuses display this malformation after irradiation with 1 Gy. The C57BL-strain does not show the increased frequency of gastroschisis after radiation-exposure to the zygotes. The genetic background of this malformation was investigated in a backcross of HLG x C57BL females to HLG males. The pregnant HLG x C57BL females were irradiated in a stage in which the (HLG x C57BL) x HLG [BC1] embryos were in the 1-cell stage. The frequency of gastroschisis in the BC1 generation was compared with a genetic model of a single recessive mutation with 11% penetrance. This frequency does not fit a single-locus inheritance. The number of loci involved was estimated to be about two or three. HLG mouse strain may be a valuable animal model in the study of polygenic traits.

Citations

Dec 7, 2005·Pediatric Surgery International·A MortellP Puri
Dec 16, 2000·BJOG : an International Journal of Obstetrics and Gynaecology·J I CurryM D Stringer
Feb 18, 2003·European Journal of Clinical Investigation·S HillebrandtF Lammert
Jan 19, 2007·American Journal of Medical Genetics. Part a·Marcia L FeldkampThomas W Sadler
Aug 7, 2019·Birth Defects Research·Marcia L FeldkampNicola J Camp
May 29, 2019·International Journal of Radiation Biology·Christian Streffer
Oct 4, 2012·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·P Jacquet

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