PMID: 11901359Mar 20, 2002Paper

Genetic analysis of the (CTG)n NOTCH4 polymorphism in 65 multiplex bipolar pedigrees

Psychiatric Genetics
T Swift-ScanlanM G McInnis

Abstract

A strong genetic association between the NOTCH4 locus on chromosome 6 and schizophrenia was recently reported. Based on the data suggesting overlapping susceptibility for schizophrenia and bipolar disorder, we genotyped the polymorphic (CTG)n encoding polyleucine repeat in exon 1 of NOTCH4 in 65 pedigrees ascertained for a genetic linkage study of bipolar disorder. In addition, we analyzed a subset of our pedigrees with psychotic features at this locus. We failed to find any association between the (CTG)n NOTCH4 polymorphism and either the bipolar or the psychotic bipolar phenotype in our 65 pedigrees.

References

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Oct 3, 1999·Schizophrenia Research·D B WildenauerS D Detera-Wadleigh
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Aug 2, 2001·The American Journal of Psychiatry·J B PotashM G McInnis

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Citations

Oct 12, 2011·Journal of Molecular Neuroscience : MN·Thalita Cristina Figueiredo, João Ricardo Mendes de Oliveira
Feb 28, 2004·Clinical Genetics·J A HarperC J Guidos
Mar 11, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·A D SkolM T Tsuang

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