Genetic analysis of the difference in diet-induced atherosclerosis between the inbred mouse strains SM/J and NZB/BINJ

Arteriosclerosis, Thrombosis, and Vascular Biology
W A PitmanB Paigen

Abstract

To identify the genetic factors affecting susceptibility to atherosclerosis, we studied the inheritance of plasma total cholesterol (TC) and HDL cholesterol (HDL-C) concentrations and susceptibility to atherosclerotic lesion formation in an (SM/J[SM] x NZB/B1NJ[NZB]) outcross, an (SM/NZB)FI[F1] x SM backcross, and the NXSM recombinant inbred (RI) strain set. After 18 or 26 weeks on the atherogenic diet, lesion sizes in female mice were 160+/-110 (SE) microm2 for NZB, 100+/-60 for F1, and 3800+/-920 for SM. After 0, 4, or 26 weeks on the atherogenic diet, NZB had higher TC and HDL-C levels than either SM or F1. The F1 progeny had TC and HDL-C levels slightly higher than or similar to the SM/J parent, while lesion size in the F1 progeny was more similar to the NZB parent. Among the 15 RI strains, 8 resembled NZB and F1, 3 resembled SM, and 4 were intermediate between NZB and SM for lesion size. For the (SM x NZB)F1 x SM backcross offspring, 26 resembled NZB and F1, 7 resembled SM, and 6 were intermediate between NZB and SM for lesion size. There was poor correlation between lesion size and plasma TC or HDL-C in the parental strains and the backcross. These data suggest that resistance to atherosclerosis is determined by at least ...Continue Reading

References

Mar 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·B PaigenD Albee
Mar 1, 1989·Trends in Genetics : TIG·M R Capecchi
Jun 10, 1988·Science·R Jaenisch
Dec 1, 1987·Atherosclerosis·B PaigenR A Williams
Aug 1, 1995·The American Journal of Clinical Nutrition·B Paigen
Jun 1, 1994·Nature Genetics·W F DietrichR D Dredge
Aug 1, 1994·Current Opinion in Lipidology·B PaigenE M Rubin
Jan 1, 1994·Annual Review of Physiology·J L Breslow
Oct 1, 1993·Science·N G CopelandS E Lincoln
Jan 1, 1993·Mammalian Genome : Official Journal of the International Mammalian Genome Society·K F Manly
Mar 14, 1996·Nature·W F DietrichT J O'Connor
May 3, 1996·Science·J L Breslow
Nov 1, 1995·Molecular Medicine Today·D M ShihA J Lusis

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Citations

Aug 6, 2011·Cellular and Molecular Life Sciences : CMLS·Kim S MidwoodGertraud Orend
Apr 19, 2005·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Malcolm A LyonsGary A Churchill
Jan 25, 2002·Annals of the New York Academy of Sciences·J D SmithJ L Breslow
Sep 23, 2003·Current Opinion in Lipidology·Jonathan Smith
Jan 3, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Grith L SorensenUffe Holmskov

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