Genetic analysis of the Drosophila alphaPS2 integrin subunit reveals discrete adhesive, morphogenetic and sarcomeric functions.

Genetics
J W Bloor, N H Brown

Abstract

The integrin family of cell surface receptors mediates cell-substrate and cell-to-cell adhesion and transmits intracellular signals. In Drosophila there is good evidence for an adhesive role of integrins, but evidence for integrin signalling has remained elusive. Each integrin is an alphabeta heterodimer, and the Drosophila betaPS subunit forms at least two integrins by association with different alpha subunits: alphaPS1betaPS (PS1) and alphaPS2betaPS (PS2). The complex pattern of PS2 integrin expression includes, but is more extensive than, the sites where PS2 has a known requirement. In order to investigate whether PS2 integrin is required at these additional sites and/or has functions besides mediating adhesion, a comprehensive genetic analysis of inflated, the gene that encodes alphaPS2, was performed. We isolated 35 new inflated alleles, and obtained 10 alleles from our colleagues. The majority of alleles are amorphs (36/45) or hypomorphs (4/45), but five alleles that affect specific developmental processes were identified. Interallelic complementation between these alleles suggests that some may affect distinct functional domains of the alphaPS2 protein, which specify particular interactions that promote adhesion or signa...Continue Reading

References

Dec 2, 1990·Cell Differentiation and Development : the Official Journal of the International Society of Developmental Biologists·M Wilcox
Mar 1, 1990·Genes & Development·T XuS Artavanis-Tsakonas
Nov 16, 1989·Nature·D L Brower, S M Jaffe
Jul 1, 1986·Genetics·R Steward, C Nüsslein-Volhard
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A J MacKrellJ H Fessler
Mar 1, 1985·Developmental Biology·D L BrowerL A Reger
Jul 1, 1971·Journal of Morphology·M A Goldstein, W J Burdette
Jun 1, 1967·Journal of Ultrastructure Research·E B SandbornJ J Roberge
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·D L BrowerL A Reger
Dec 1, 1993·Cell Adhesion and Communication·M ZavortinkD L Brower
Apr 14, 1995·Science·E A Clark, J S Brugge
May 1, 1995·The Journal of Cell Biology·S N GettnerL F Reichardt
Oct 1, 1994·Current Opinion in Cell Biology·P J GotwalsR O Hynes
Feb 1, 1994·The Journal of Cell Biology·M C HreskoR H Waterston
Sep 1, 1993·Mechanisms of Development·M WehrliM Wilcox
Jun 1, 1993·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·N H Brown
May 1, 1993·Developmental Biology·M C Brabant, D L Brower
Feb 1, 1996·Current Opinion in Cell Biology·S W Craig, R P Johnson
Jan 7, 1997·Proceedings of the National Academy of Sciences of the United States of America·T A Springer
Feb 1, 1960·The Journal of Experimental Zoology·T R WRIGHT
May 1, 1993·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Rachel DrysdaleMichael Bate

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Citations

Jun 15, 2004·Molecular Biology of the Cell·Alison L JannuziDanny L Brower
Oct 2, 2003·Current Opinion in Cell Biology·Danny L Brower
Jul 1, 2005·Physiological Reviews·Scott L Hooper, Jeffrey B Thuma
Sep 27, 2002·Genesis : the Journal of Genetics and Development·Espen EnerlyAndrew Lambertsson
May 3, 2006·Developmental Biology·Su Hao Lo
Oct 4, 2002·Developmental Cell·Christian Bökel, Nicholas H Brown
Jan 2, 2008·The Journal of Cell Biology·Klodiana Jani, Frieder Schöck
Sep 14, 2020·Journal of Molecular and Cellular Cardiology·Thomas G Martin, Jonathan A Kirk
May 8, 2007·Mechanisms of Development·Bhavna ChananaGerd Vorbrüggen
Jul 10, 2007·Developmental Biology·Danelle DevenportNicholas H Brown
Jun 23, 2000·Developmental Biology·N H BrownM D Martin-Bermudo
Oct 7, 2008·The Journal of Biological Chemistry·Liping ZhangKelly G Ten Hagen
Sep 17, 2003·Insect Molecular Biology·M D Lavine, M R Strand
Aug 11, 2000·Matrix Biology : Journal of the International Society for Matrix Biology·N H Brown
Aug 23, 2000·The Journal of Cell Biology·Y HuangC Wu
Mar 30, 2011·Journal of Cell Science·Christos G ZervasNicholas H Brown
Feb 5, 2009·Nature Reviews. Molecular Cell Biology·John C Sparrow, Frieder Schöck
May 15, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Klodiana Jani, Frieder Schöck
Sep 3, 2010·PloS One·Nadezhda TikhmyanovaErica A Golemis
Dec 3, 2010·PLoS Genetics·Yanning RuiNorbert Perrimon
Jun 15, 2011·Biophysics Reviews·Garland L Crawford, Robert Horowits

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