PMID: 8946475Oct 1, 1996Paper

Genetic analysis of the human cytochrome P450 CYP2C9 locus

Pharmacogenetics
M J StubbinsC R Wolf

Abstract

Cytochrome P450 CYP2C9 metabolizes a wide variety of clinically important drugs, including phenytoin, tolbutamide, warfarin and a large number of non-steroidal anti-inflammatory drugs. Previous studies have shown that even relatively conservative changes in the amino acid composition of this enzyme can affect both its activity and substrate specificity. To date six different human CYP2C9 cDNA sequences, as well as the highly homologous CYP2C10 sequence have been reported suggesting that the CYP2C9 gene is polymorphic. Only nine single base substitutions in the coding region of CYP2C9 account for the differences seen between the CYP2C9 proteins. In this report we have developed polymerase chain reaction (PCR)-based assays to distinguish all seven sequences, and have determined their allele frequencies in the Caucasian population. Of the seven sequences studied in one hundred individuals only three appeared to be CYP2C9 alleles. These alleles termed CYP2C9*1, CYP2C9*2 and CYP2C9*3 had allele frequencies of 0.79, 0.125 and 0.085 respectively. The CYP2C10 gene could not be found in any of the samples studied. The assays developed here will allow the prediction of CYP2C9 phenotype, thus identifying those individuals who may exhibit ...Continue Reading

Citations

Dec 10, 2003·Archives of Pharmacal Research·Sukhyang LeeJeong Hee Kim
Mar 19, 2005·European Journal of Clinical Pharmacology·Heydy V Bravo-VillaltaRyuya Horiuchi
Jun 8, 2006·European Journal of Clinical Pharmacology·Myong-Jin KimJoseph S Bertino
Aug 12, 2009·European Journal of Clinical Pharmacology·Melanie S JoyJoyce A Goldstein
Oct 13, 2006·Pediatric Cardiology·K KosakiT Takahashi
Jul 31, 2007·Journal of Thrombosis and Thrombolysis·John F CarlquistJeffrey L Anderson
Mar 4, 2009·Journal of General Internal Medicine·Mark H EckmanJonathan Rosand
Mar 31, 2004·La Revue de médecine interne·V SiguretE Pautas
Jun 20, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·M W Linder
Nov 27, 1999·Molecular Aspects of Medicine·J A Hasler
Apr 13, 2000·Pharmacology & Therapeutics·K Nakagawa, T Ishizaki
Oct 31, 2002·Advanced Drug Delivery Reviews·Hong-Guang XieC Michael Stein
Mar 26, 2002·Cancer Letters·Elena García-MartínJosé A G Agúndez
Aug 1, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·K R HenneA E Rettie
May 14, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Pedro DoradoAdrián LLerena
Mar 23, 2002·The Pharmacogenomics Journal·R KerbU Brinkmann
Apr 22, 2009·The Pharmacogenomics Journal·William C SpeedKenneth K Kidd
Jun 26, 2001·British Journal of Clinical Pharmacology·J H MartinM L Barclay
Oct 27, 2001·British Journal of Clinical Pharmacology·M G ScordoM Ingelman-Sundberg
Jul 15, 1998·British Journal of Clinical Pharmacology·J O Miners, D J Birkett
Apr 23, 2002·British Journal of Clinical Pharmacology·Ann K DalyGuruprasad P Aithal
Jan 22, 2003·British Journal of Clinical Pharmacology·Julia KirchheinerJürgen Brockmöller
Feb 7, 2003·The New England Journal of Medicine·Richard Weinshilboum
Feb 1, 2012·Genetic Testing and Molecular Biomarkers·Seyed Mohammad Bagher Hashemi-SotehMohammad-Reza Shiran
Oct 27, 2009·The Journal of Pharmacology and Experimental Therapeutics·Amarjit S ChaudhryErin G Schuetz
Aug 10, 2007·Molecular Pharmacology·Lian WeiTimothy S Tracy
Jun 3, 2000·Annual Review of Pharmacology and Toxicology·S Broder, J C Venter
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·H G XieC M Stein
Apr 12, 2005·Annual Review of Pharmacology and Toxicology·Allan E Rettie, Jeffrey P Jones
Aug 29, 2000·Anesthesia and Analgesia·M SueyasuR Oishi
Aug 1, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Helena BuzkováOndrej Slanar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved