PMID: 15366371Sep 16, 2004Paper

Genetic analysis of X-linked hybrid sterility in the house mouse

Mammalian Genome : Official Journal of the International Mammalian Genome Society
Radka StorchováJiri Forejt

Abstract

Hybrid sterility is a common postzygotic reproductive isolation mechanism that appears in the early stages of speciation of various organisms. Mus musculus musculus and Mus musculus domesticus represent two recently separated mouse subspecies particularly suitable for genetic studies of hybrid sterility. Here we show that the introgression of Chr X of M. m. musculus origin (PWD/Ph inbred strain, henceforth PWD) into the genetic background of the C57BL/6J (henceforth B6) inbred strain (predominantly of M. m. domesticus origin) causes male sterility. The X-linked hybrid sterility is associated with reduced testes weight, lower sperm count, and morphological abnormalities of sperm heads. The analysis of recombinant Chr Xs in sterile and fertile males as well as quantitative trait locus (QTL) analysis of several fertility parameters revealed an oligogenic nature of the X-linked hybrid sterility. The Hstx1 locus responsible for male sterility was mapped near DXMit119 in the central part of Chr X. To ensure full sterility, the PWD allele of Hstx1 has to be supported with the PWD allelic form of loci in at least one proximal and/or one distal region of Chr X. Mapping and cloning of Hstx1 and other genes responsible for sterility of B6...Continue Reading

Citations

Nov 17, 2007·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Hongguang ShaoMichael G Tordoff
Sep 11, 2012·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Joseph H NadeauToshihiko Shiroishi
Aug 4, 2007·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·P Jeremy Wang, Jieyan Pan
Jul 23, 2013·Nature Genetics·Jacob L MuellerDavid C Page
Jan 19, 2013·Proceedings of the National Academy of Sciences of the United States of America·Tanmoy BhattacharyyaJiri Forejt
May 10, 2011·Genome Biology and Evolution·Seong Hwan ParkJianzhi Zhang
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Oct 31, 2012·Evolution; International Journal of Organic Evolution·Maria Dzur-GejdosovaJiri Forejt

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