Genetic ancestry is associated with measures of subclinical atherosclerosis in African Americans: the Jackson Heart Study

Arteriosclerosis, Thrombosis, and Vascular Biology
Samson Y GebreabSharon K Davis

Abstract

To determine whether genetic ancestry was associated with subclinical atherosclerosis measures after adjustment for traditional cardiovascular disease risk factors, inflammatory marker, socioeconomic status, and psychosocial factors in a large admixed African American population. Participants were drawn from the Jackson Heart Study. Participant's percent of European ancestry (PEA) was estimated based on 1747 genetic markers using HAPMIX. Association of PEA with peripheral arterial disease and common carotid intima-media thickness were investigated among 2168 participants and with coronary artery calcification >0 and abdominal aortic calcification >0 among 1139 participants. The associations were evaluated using multivariable regression models. Our results showed that a 1 SD increase in PEA was associated with a lower peripheral arterial disease prevalence after adjusting for age and sex (prevalence ratio=0.90 [95% CI, 0.82-0.99]; P=0.036). Adjustments for traditional cardiovascular disease risk factors, socioeconomic status, and psychosocial factors attenuated this association (prevalence ratio=0.91 [0.82-1.00]; P=0.046). There was also a nonlinear association between PEA and coronary artery calcification and abdominal aortic c...Continue Reading

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Citations

Dec 25, 2012·Journal of Biomechanics·Frank GijsenJolanda Wentzel
Mar 13, 2018·American Journal of Hypertension·John N BoothAdam P Bress
Jan 29, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Claudia CalcagnoZahi A Fayad
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Sep 17, 2020·American Journal of Physical Anthropology·Ken BataiRick A Kittles
Jul 10, 2021·Circulation. Genomic and Precision Medicine·Yingchang LuMaggie C Y Ng

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