Genetic and antigenic diversity among noroviruses

The Journal of General Virology
Grant S HansmanNaokazu Takeda

Abstract

Human norovirus (NoV) strains cause a considerable number of outbreaks of gastroenteritis worldwide. Based on their capsid gene (VP1) sequence, human NoV strains can be grouped into two genogroups (GI and GII) and at least 14 GI and 17 GII genotypes (GI/1-14 and GII/1-17). Human NoV strains cannot be propagated in cell-culture systems, but expression of recombinant VP1 in insect cells results in the formation of virus-like particles (VLPs). In order to understand NoV antigenic relationships better, cross-reactivity among 26 different NoV VLPs was analysed. Phylogenetic analyses grouped these NoV strains into six GI and 12 GII genotypes. An antibody ELISA using polyclonal antisera raised against these VLPs was used to determine cross-reactivity. Antisera reacted strongly with homologous VLPs; however, a number of novel cross-reactivities among different genotypes was observed. For example, GI/11 antiserum showed a broad-range cross-reactivity, detecting two GI and 10 GII genotypes. Likewise, GII/1, GII/10 and GII/12 antisera showed a broad-range cross-reactivity, detecting several other distinct GII genotypes. Alignment of VP1 amino acid sequences suggested that these broad-range cross-reactivities were due to conserved amino ac...Continue Reading

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Citations

Jun 27, 2009·Journal of Biochemistry·Yuichi Someya, Naokazu Takeda
May 7, 2010·Journal of Clinical Microbiology·Jacqueline XerryJim J Gray
Apr 26, 2013·Journal of Clinical Microbiology·Vipin Kumar MenonGagandeep Kang
Feb 3, 2007·Journal of Clinical Microbiology·Grant S HansmanNaokazu Takeda
Jun 6, 2009·Journal of Clinical Microbiology·Maria LysénKjell-Olof Hedlund
Jun 12, 2009·Journal of Virology·Kyeong-Ok Chang
Aug 3, 2012·Journal of Virology·Tomomi KubotaHaruko Shirato
Jul 5, 2007·Journal of Virology·J Joukje SiebengaMarion Koopmans
Aug 15, 2008·Journal of Virology·Haruko ShiratoNaokazu Takeda
Aug 10, 2007·Journal of Virology·Tian-Cheng LiNaokazu Takeda
Mar 25, 2008·Uirusu·Haruko Shirato-Horikoshi, Naokazu Takeda
Sep 21, 2010·Uirusu·Hironori Sato
Feb 9, 2008·Emerging Infectious Diseases·Grant S HansmanNaokazu Takeda
May 15, 2013·International Journal of Genomics·Che-Lun Hung, Chun-Yuan Lin
May 27, 2014·Emerging Infectious Diseases·Gabriel I Parra, Kim Y Green
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Aug 29, 2012·Microbiology and Immunology·Noritoshi KitamotoTomoyuki Tanaka
Jul 25, 2012·Microbiology and Immunology·Sanghun ParkHyunsoo Kim

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