Genetic and antigenic typing of border disease virus (BDV) isolates from Italy reveals the existence of a novel BDV group

Veterinary Microbiology
M GiammarioliG M De Mia

Abstract

Border disease virus belongs to the Pestivirus genus, within the family Flaviviridae. Genetic analysis of pestiviruses isolated from sheep in continental Europe have led to the proposal that BDV isolates are segregated into at least seven clusters. In 2005 the molecular analysis of an Italian caprine BDV strain provided evidence for the presence of an atypical pestivirus, which may represent the first member of a putative novel pestivirus sub-group. To further build on this study, ovine pestivirus strains were isolated from small ruminant flocks and characterized both genetically and antigenically. A defined section of the 5'UTR and the complete N(pro) coding region were amplified and used for phylogenetic analysis. This revealed that these pestiviruses belong to the BDV species but differed significantly from all previously described ovine pestiviruses providing evidence for the presence of a novel genetic group. Four of the five isolates were also typed antigenically with a panel of pestivirus specific mAbs directed against NS2/3, E(rns) and E2 proteins. The four isolates reacted with a distinct set of mAbs, in particular against the BDV-E2 and the BDV-E(rns) epitopes. The isolates were greatly reactive for E(rns) and NS2/3 m...Continue Reading

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Citations

Apr 17, 2014·Veterinary Microbiology·Nahoko KawanishiShunji Yamada
May 4, 2012·New Zealand Veterinary Journal·A M J McFaddenA M Weir
Feb 7, 2016·Comparative Immunology, Microbiology and Infectious Diseases·Niranjan MishraD D Kulkarni
Jan 7, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Matheus Nunes WeberCláudio Wageck Canal
Apr 3, 2016·Tropical Animal Health and Production·Pelin Tuncer-GöktunaKadir Yeşilbağ
Apr 5, 2016·Transboundary and Emerging Diseases·S CiulliA Guercio
Nov 24, 2016·Transboundary and Emerging Diseases·N DecaroG Elia
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Jan 17, 2020·Transboundary and Emerging Diseases·Cristina CasciariGian Mario De Mia
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Oct 27, 2021·Veterinary Research Communications·Hasbi Sait SaltikKamil Atli

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