PMID: 7545972Sep 1, 1994Paper

Genetic and antigenic variability of HIV type 1 in Brazil

AIDS Research and Human Retroviruses
J C Couto-FernandezG van der Groen

Abstract

Six Brazilian strains of human immunodeficiency virus type 1 (HIV-1) were isolated from infected individuals residing in different regions of Brazil between 1987 and 1989. Phylogenetic analysis based on an 860-base pair env fragment, including V3, V4, V5, and the beginning of gp41, classified the Brazilian strains significantly in genotype B, with interhost distances between 5.9 and 13.1% (mean value, 10%). Amino acid sequence analysis of the V3 loop revealed that three strains contained the North American/European GPGR motif as the tip of the loop whereas in the other three strains proline (P) was substituted by tryptophan (W), methionine (M), or phenylalanine (F). A consensus peptide, Bra-cons, was designed containing GWGR as the tip of the loop. Serological reactivity to the Bra-cons peptide and other V3 peptides (MN, SF2, HBX2, RF, MAL, ELI, Z6, and a Côte d'Ivoire peptide, CI-cons) was compared for 114 HIV-1-positive sera from Rio de Janeiro. Sixty-nine sera (60.5%) reacted with peptides belonging to genotype B, of which 10 sera also reacted with peptides belonging to genotype A (n = 7) and D (n = 3). Eighteen sera (15.8%) had binding antibodies to the Bra-cons peptide. A high number of sera (n = 43; 37.7%) had no antibodi...Continue Reading

References

Aug 1, 1992·AIDS Research and Human Retroviruses·B KorberG Myers
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Citations

May 30, 2001·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·M L GuimarãesM G Morgado
Oct 1, 1995·Nature Medicine·J E Osborn
Nov 4, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Adriana de BritoJorge Casseb
Sep 1, 1995·AIDS Research and Human Retroviruses·A CabelloA Von Brunn
Oct 27, 1998·AIDS Research and Human Retroviruses·M AbidA Benslimane
Feb 24, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·C DevitoH Wigzell
Mar 4, 2006·AIDS·Gonzalo BelloMariza G Morgado
Jan 7, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J CassebR Michael-Hendry
Mar 8, 2003·Revista Da Sociedade Brasileira De Medicina Tropical·Ana Maria Barral de MartínezCarlos Maurício de Figueiredo Antunes
Jun 10, 2017·International Journal of STD & AIDS·Beatris M MartinSonia M Raboni
Apr 19, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·J C Couto-FernandezB Galvão-Castro

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