[Genetic and biochemical mechanisms of involvement of antioxidant defense enzymes in the development of bronchial asthma].

Biomedit︠s︡inskai︠a︡ khimii︠a︡
A V PolonikovM A Solodilova

Abstract

In the present review we have analyzed and summarized recent literature data on genetic and biochemical mechanisms responsible for involvement of antioxidant defense enzymes in the etiology and pathogenesis of bronchial asthma. It has been shown that the mechanisms of asthma development are linked with genetically determined abnormalities in the functioning of antioxidant defense enzymes. These alterations are accompanied by a systemic imbalance between oxidative and anti-oxidative reactions with the shift of the redox state toward increased free radical production and oxidative stress, a key element in the pathogenesis of bronchial asthma.

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Citations

Jul 14, 2018·The Plant Journal : for Cell and Molecular Biology·Kristian Mark P CaldoM Joanne Lemieux

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