PMID: 8939624Oct 1, 1996Paper
Genetic and biochemical probes for protein-protein interactions
Current Opinion in Biotechnology
D S McNabb, L Guarente
Abstract
The two-hybrid system is a powerful approach for examining protein-protein interactions. Recently, the utility of the system has been extended to include the genome-wide mapping of protein-protein interactions and the identification of peptide inhibitors of protein interactions. In addition, immunophilins and their chemical ligands are providing useful reagents for generating conditional protein-protein interactions in vivo to dissect intracellular signaling pathways.
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