Genetic and cellular studies highlight that A Disintegrin and Metalloproteinase 19 is a protective biomarker in human prostate cancer

BMC Cancer
Gerard HoyneVance Matthews

Abstract

Prostate cancer is the second most frequently diagnosed cancer in men worldwide. Current treatments include surgery, androgen ablation and radiation. Introduction of more targeted therapies in prostate cancer, based on a detailed knowledge of the signalling pathways, aims to reduce side effects, leading to better clinical outcomes for the patient. ADAM19 (A Disintegrin And Metalloproteinase 19) is a transmembrane and soluble protein which can regulate cell phenotype through cell adhesion and proteolysis. ADAM19 has been positively associated with numerous diseases, but has not been shown to be a tumor suppressor in the pathogenesis of any human cancers. Our group sought to investigate the role of ADAM19 in human prostate cancer. ADAM19 mRNA and protein levels were assessed in well characterised human prostate cancer cohorts. ADAM19 expression was assessed in normal prostate epithelial cells (RWPE-1) and prostate cancer cells (LNCaP, PC3) using western blotting and immunocytochemistry. Proliferation assays were conducted in LNCaP cells in which ADAM19 was over-expressed. In vitro scratch assays were performed in PC3 cells over-expressing ADAM19. Immunohistochemical studies highlighted that ADAM19 protein levels were elevated in ...Continue Reading

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Citations

Sep 7, 2016·Disease Markers·Peng WuSong Wu
Mar 8, 2017·Mediators of Inflammation·Lakshini WeerasekeraVance B Matthews
Apr 4, 2021·International Journal of Molecular Sciences·Marley J Binder, Alister C Ward

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Datasets Mentioned

BETA
GSE40272

Methods Mentioned

BETA
RNA-seq
FCS
electrophoresis
transfection
enzyme-linked immunosorbent assay
biopsies
transfections

Software Mentioned

R affy
GraphPad
limma
R
R graphics
R survival
GraphPad Prism6

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