PMID: 9536296Jan 1, 1997Paper

Genetic and environmental components of the population variance in bone density

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Ego Seeman, J L Hopper

Abstract

Understanding of the genetic and environmental factors contributing to the differences in fracture rates between young and old, between women and men, and between races is limited. The reasons for this may partly relate to the lack of a detailed understanding of the structural basis of bone fragility. This information, although difficult to obtain because of the invasiveness of bone biopsy, will be required if advances are to occur. aBMD cannot be relied upon as an endpoint in the study of the pathophysiology of osteoporosis. Advances will require the description of the age-, gender and race-specific means and variances in trabecular number, thickness, spacing and orientation, cortical thickness, and bone size and shape in women and men of different racial groups. Subsequent comparison of the structures in young versus old, female versus male, and in racial groups may reveal the structural differences from which inferences may be made concerning the differences in fracture rates between these groups. By defining the structural basis for bone fragility, the genetic and modifiable environmental determinants of these structures may then be identified, providing hypotheses to be tested in randomized trials aimed at reducing the inc...Continue Reading

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Citations

Jul 18, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A MavroeidiH M Macdonald
Dec 22, 2006·The Proceedings of the Nutrition Society·Ann PrenticeGail R Goldberg
Jun 24, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·David KarasikDouglas P Kiel
Sep 24, 1999·The Journal of Clinical Investigation·S BassE Seeman
Nov 8, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S M PluijmP Lips
Aug 31, 2013·PloS One·Pornrutsami JintaridthApiwat Mutirangura
May 3, 2005·Calcified Tissue International·M A Brown
Apr 20, 2001·The Proceedings of the Nutrition Society·A Prentice
Feb 24, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ozgur OktemFatih Durmusoglu
Apr 17, 2008·The Proceedings of the Nutrition Society·Susan A Lanham-New
Jul 20, 1999·Current Opinion in Rheumatology·S FerrariJ P Bonjour
May 1, 2001·Physiological Genomics·T A DrakeA J Lusis

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