Genetic and environmental contributions to depression in Sri Lanka.

The British Journal of Psychiatry : the Journal of Mental Science
Harriet A BallMatthew Hotopf

Abstract

Susceptibility to depression results from genetic and non-familially shared environmental influences in high-income, Western countries. Environments may play a different role for populations in different contexts. To examine heritability of depression in the first large, population-based twin study in a low-income country. Lifetime depression and a broader measure of depression susceptibility (D-probe) were assessed in 3908 adult twins in Sri Lanka (the CoTASS study). There were gender differences for the broad definition (D-probe), with a higher genetic contribution in females (61%) than males (4%). Results were similar for depression, but the prevalence was too low to estimate heritability for males. Genetic influences on depression in women appear to be at least as strong in this Sri Lankan sample as in higher-income countries. Conclusions are less clear for men but suggest a larger role for environments rather than genes. The nature as well as the magnitude of environmental influences may also differ across populations.

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Citations

Jan 11, 2013·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Athula SumathipalaDinesha Gunewardane
Feb 15, 2011·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Harriet A BallMatthew Hotopf
Aug 4, 2010·The British Journal of Psychiatry : the Journal of Mental Science·Harriet A BallMatthew Hotopf
Mar 12, 2013·Journal of Affective Disorders·Chun-Hong LiuChuan-Yue Wang
Jun 11, 2019·Psychological Medicine·Yusuke TakahashiJuko Ando
Sep 5, 2019·Social Psychiatry and Psychiatric Epidemiology·Helena M S ZavosFrühling V Rijsdijk
May 21, 2019·Global Health, Epidemiology and Genomics·Moritz P HerleFrühling Rijsdijk
Sep 10, 2020·Cold Spring Harbor Perspectives in Medicine·Tom A McAdamsJean-Baptiste Pingault

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