Genetic and environmental factors in epilepsy: a population-based study of 11900 Danish twin pairs

Epilepsy Research
M J KjeldsenM L Friis

Abstract

The contribution of genetic and environmental factors to the occurrence of epilepsy was examined in an unselected sample of twins recruited from the population-based Danish Twin Registry. Information on the occurrence of epilepsy in both members of a twin pair was obtained from 11900 pairs whose ages ranged from 12 to 41 years. Concordance rates, odds ratios and tetrachoric correlations were used to quantify the similarity of monozygotic (MZ) and dizygotic (DZ) twins. The sample was stratified by sex and separated into two age cohorts for analysis. Significantly higher probandwise concordance rates were found for MZ compared with DZ twins (0.37 and 0.08, P<0.01). Odds ratios and tetrachoric correlation showed similar pattern. An etiological model including additive genetic and individual specific environmental factors provided the best overall fit to the data, with 70 and 88% of the liability to develop epilepsy being accounted for by genetic factors in the younger and older cohorts, respectively. Individual specific environmental factors explained the remaining 30 and 12%, respectively. In conclusion, this study has confirmed the substantial impact, which genetic factors have in the etiology of epilepsy. The heritability of ep...Continue Reading

References

May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A E LehesjokiA de la Chapelle
Dec 1, 1991·Acta Neurologica Scandinavica·M SillanpääJ Kaprio
Sep 1, 1988·American Journal of Medical Genetics·D A GreenbergP I Terasaki
Dec 1, 1982·International Journal of Epidemiology·R CederlöfS Sarna
May 1, 1995·Nature Genetics·R OttmanM L Scheuer
Jun 1, 1995·International Journal of Epidemiology·K O KyvikH Beck-Nielsen
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·E TahvanainenA de la Chapelle
Dec 1, 1993·Neurology·S F BerkovicJ L Hopper
Mar 1, 1997·Human Molecular Genetics·M GuipponiA Malafosse
May 1, 1997·QJM : Monthly Journal of the Association of Physicians·C H Hawkes
Dec 17, 1997·Nature Genetics·N MartinG Machin
Apr 18, 1998·Annals of Neurology·S F BerkovicJ L Hopper
May 5, 1999·Current Opinion in Neurology·M Leppert, N Singh
Dec 1, 1999·American Journal of Human Genetics·L XiongM Pandolfo
Jul 15, 2000·Journal of Neurology·R M Gardiner
May 1, 1960·The Journal of Nervous and Mental Disease·E INOUYE
Oct 31, 2003·Expert Reviews in Molecular Medicine·L Bate, M Gardiner
Jun 9, 1951·Journal of the American Medical Association·W G LENNOX

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Citations

Sep 7, 2002·Mental Retardation and Developmental Disabilities Research Reviews·Linda D Cowan
Sep 28, 2002·Epilepsy Research·Marianne Juel KjeldsenKaare Christensen
Jun 5, 2010·Brain : a Journal of Neurology·Dalia KasperaviciūteSanjay M Sisodiya
Aug 17, 2006·Neuroepidemiology·Kari HemminkiJan Sundquist
Jul 30, 2014·Brain : a Journal of Neurology·Doug SpeedMichael R Johnson
Feb 28, 2007·Studies in History and Philosophy of Biological and Biomedical Sciences·Christopher H Pearson
May 11, 2006·Statistics in Medicine·Jason Kunming Huang, John Jen Tai
Jun 8, 2004·Acta Neurologica Scandinavica·S JainR M Pandey
Sep 1, 2015·Current Neurology and Neuroscience Reports·Ryan S Dhindsa, David B Goldstein
Sep 6, 2011·Epilepsy & Behavior : E&B·Michael R Johnson, Simon D Shorvon
Mar 15, 2013·Biochemical and Biophysical Research Communications·Young-Soo BaeMyoung-Hwan Kim
Sep 23, 2008·Early Human Development·Niyati MukherjeeJohn H Gilmore
Aug 3, 2005·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Ali Akbar Asadi-Pooya
Sep 28, 2016·NeuroImage. Clinical·Saud AlhusainiPaul M Thompson
Mar 1, 2017·Seizure : the Journal of the British Epilepsy Association·Devyn CotterAidan Neligan
Mar 1, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Nelson L S TangJack Chun-Yiu Cheng
Nov 5, 2002·Nature Reviews. Genetics·Dorret BoomsmaLeena Peltonen
Dec 7, 2005·European Journal of Epidemiology·Mogens VestergaardJørn Olsen
Mar 30, 2006·Epidemiology·Yuelian SunJørn Olsen
Nov 24, 2015·Annual Review of Vision Science·Felix GrassmannBernhard H F Weber
Sep 7, 2018·Molecular Brain·Jing LiuBaomin Li
Dec 24, 2018·Epilepsia·Frederik S AhlersJakob Christensen
Feb 27, 2016·Genome Medicine·Holly A F StessmanEvan E Eichler
Jul 12, 2018·Clinical Genetics·K A MyersD A Dyment
Jun 6, 2018·Biology of Sex Differences·Yanyan MaoYuelian Sun
Aug 26, 2016·G3 : Genes - Genomes - Genetics·Arunesh Saras, Mark A Tanouye
Feb 24, 2021·Disease Models & Mechanisms·Grant F MarshallCatherine M Abbott
May 2, 2021·Molecular and Cellular Neurosciences·Claire S LeblondThomas Bourgeron
Sep 8, 2021·Frontiers in Genetics·Mark Z KosCharles Ákos Szabó

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